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CAS RN: 91421-43-1 | Product Number: A2063

9-Aminocamptothecin


Purity: >95.0%(HPLC)
Synonyms:
Documents:
10MG
€319.00
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Product Number A2063
Purity / Analysis Method >95.0%(HPLC)
Molecular Formula / Molecular Weight C__2__0H__1__7N__3O__4 = 363.37  
Physical State (20 deg.C) Solid
CAS RN 91421-43-1
Reaxys Registry Number 4276593
PubChem Substance ID 87560557
Merck Index (14) 431
MDL Number

MFCD00909855

Specifications
Appearance Light yellow to Yellow to Orange powder to crystal
Purity(HPLC) min. 95.0 area%
Properties (reference)
GHS
Related Laws:
RTECS# UQ0490500
Transport Information:
HS Number 2939790090
Application
9-Aminocamptothecin (9-AC): A Water Insoluble Topoisomerase-I Inhibitor

9-Aminocamptothecin (9-AC) is a water insoluble derivative of camptothecin [C1495] with broad antitumor activity, and a metabolite of 9-nitrocamptothecin [N0822]. Camptotecin and its derivatives interfere with DNA synthesis by inhibiting the enzyme topoisomerase-I. In order to prevent and correct of topological problems caused by the DNA double helix, topoisomerase-I catalyzes the relaxation of negatively supercoiled DNA, the knotting and unknotting DNA and the linking complementary rings of single-stranded DNA into double-stranded rings. Then the inhibition action induces breaks in single strand DNA. Eventually, this leads to double-strand DNA breaks and apoptosis or cell death.

References


PubMed Literature


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