text.skipToContent text.skipToNavigation

Maximum quantity allowed is 999

Please select the quantity

CAS RN: 86639-52-3 | Product Number: E0748


Purity: >98.0%(HPLC)
  • SN-38
1   15  
2   12  

*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).

Product Number E0748
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__2__2H__2__0N__2O__5 = 392.41  
Physical State (20 deg.C) Solid
Storage Temperature <0°C
Condition to Avoid Heat Sensitive
CAS RN 86639-52-3
Reaxys Registry Number 4829984
PubChem Substance ID 87559919
MDL Number


Appearance White to Yellow to Green powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 94.0 %
Specific rotation [a]20/D +20.0 to +30.0 deg(C=0.2, THF)
Properties (reference)
Melting Point 217 °C
Specific Rotation 21.5° (C=0.2,THF)
Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 + H311 + H331 : Toxic if swallowed, in contact with skin or if inhaled.
Precautionary Statements P261 : Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water. Call a POISON CENTER/doctor if you feel unwell.
P403 + P233 : Store in a well-ventilated place. Keep container tightly closed.
Related Laws:
RTECS# UQ0491000
Transport Information:
UN Number UN1544
Class 6.1
Packing Group III
HS Number 2933998090
7-Ethyl-10-hydroxy-camptothecin (SN-38): An Active Metabolite of Irinotecan Hydrochloride (CPT-11) with a Topoisomerase-I Inhibitory Activity

7-Ethyl-10-hydroxy-camptothecin (SN-38) is a water insoluble biologically active metabolite of water soluble irinotecan hydrochloride (CPT-11) [I0714]. SN-38 has a topoisomerase-I inhibitory activity and is approximately 100-1000-fold more cytotoxic in vitro than CPT-11. Camptotecin and its derivatives interfere with DNA synthesis by inhibiting the enzyme topoisomerase-I. In order to prevent and correct of topological problems caused by the DNA double helix, topoisomerase-I catalyzes the relaxation of negatively supercoiled DNA, the knotting and unknotting DNA and the linking complementary rings of single-stranded DNA into double-stranded rings. Then the inhibition action induces breaks in single strand DNA. Eventually, this leads to double-strand DNA breaks and apoptosis or cell death. Recently, the use of polyethyleneglycolylated nanographene oxide for drug delivery of SN-38 has received widespread attention. (The product is for research purpose only.)


PubMed Literature

Safety Data Sheet (SDS) Search
Please select Language.

The requested SDS is not available.

• Please check that the Product Number you have entered is correct.

• If your information is correct and you are still not able to view the requested SDS,  please Contact Us for more information.

C of A & Other Certificates
Please enter Lot Number Incorrect Lot Number is entered
Other Documents