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Published TCIMAIL newest issue No.198
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CAS RN: 52806-53-8 | Product Number: H1600
Hydroxyflutamide
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Purity: >98.0%(HPLC)
Synonyms:
- 2-Hydroxy-4'-nitro-3'-(trifluoromethyl)isobutyranilide
- 2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propionamide
- 2-Hydroxyflutamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
€62.00
|
Contact Us | 13 |
|
| 100MG |
€185.00
|
Contact Us | 2 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | H1600 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__1H__1__1F__3N__2O__4 = 292.21 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
100MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 52806-53-8 |
| Reaxys Registry Number | 2950560 |
| PubChem Substance ID | 354334740 |
| MDL Number | MFCD00563126 |
Specifications
| Appearance | White to Brown powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 9.00 to 10.00 % |
| Melting point | 150.0 to 154.0 °C |
Properties (reference)
| Melting Point | 152 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H361 : Suspected of damaging fertility or the unborn child. H411 : Toxic to aquatic life with long lasting effects. |
| Precautionary Statements | P273 : Avoid release to the environment. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P391 : Collect spillage. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. |
Related Laws:
Transport Information:
| UN Number | UN3077 |
| Class | 9 |
| Packing Group | III |
| HS Number | 2924297099 |
Application
Hydroxyflutamide: A Pharmacologically Active Metabolite of Flutamide
Hydroxyflutamide is a pharmacologically active metabolite of flutamide [F0663] which is a non-steroidal androgen receptor antagonist with antiandrogenic activity.
References
- Characteristics of interaction of the antiandrogen flutamide with the androgen receptor in various target tissues
- Metabolism of the antiandrogenic drug (flutamide) by human CYP1A2
- Hydroxyflutamide may not always be a pure antiandrogen (a review)
- Antiandrogens: selective androgen receptor modulators (a review)
- Flutamide metabolism in four different species in vitro and identification of flutamide metabolites in human patient urine by high performance liquid chromatography/tandem mass spectrometry
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