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CAS RN: 91421-42-0 | Product Number: N0822


Purity: >98.0%(HPLC)
  • Rubitecan
1   4  

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Product Number N0822
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__2__0H__1__5N__3O__6 = 393.36  
Physical State (20 deg.C) Solid
CAS RN 91421-42-0
Reaxys Registry Number 5365063
PubChem Substance ID 87560509
Merck Index (14) 8288
MDL Number


Appearance Light orange to Yellow to Green powder to crystal
Purity(HPLC) min. 98.0 area%
Specific rotation [a]20/D +36.0 to +42.0 deg(C=0.4, CHCl3:MeOH=8:2)
Properties (reference)
Melting Point 268 °C
Specific Rotation 39° (C=0.4,CHCl3:MeOH=8:2)
Related Laws:
Transport Information:
HS Number 2939790090
水不溶性のトポイソメラーゼ I阻害剤,9-ニトロカンプトテシン (9-NC)

9-Nitrocamptothecin (9-NC) is a water insoluble derivative of camptothecin [C1495] with broad antitumor activity. Its metabolite is 9-aminocamptothecin [A2063]. Camptotecin and its derivatives interfere with DNA synthesis by inhibiting the enzyme topoisomerase-I. In order to prevent and correct of topological problems caused by the DNA double helix, topoisomerase-I catalyzes the relaxation of negatively supercoiled DNA, the knotting and unknotting DNA and the linking complementary rings of single-stranded DNA into double-stranded rings. Then the inhibition action induces breaks in single strand DNA. Eventually, this leads to double-strand DNA breaks and apoptosis or cell death.


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