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CAS RN: 29767-20-2 | Product Number: T3109

Teniposide


Purity: >98.0%(HPLC)
Synonyms:
Documents:
20MG
€41.00
1   17  
100MG
€152.00
3   18  

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Product Number T3109
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__3__2H__3__2O__1__3S = 656.66  
Physical State (20 deg.C) Solid
Storage Temperature -20°C
Condition to Avoid Heat Sensitive
CAS RN 29767-20-2
Reaxys Registry Number 7108452
PubChem Substance ID 253662241
Merck Index (14) 9145
MDL Number

MFCD00866516

Specifications
Appearance White to Almost white powder to crystaline
Purity(HPLC) min. 98.0 area%
Specific rotation [a]20/D -107.0 to -115.0 deg(C=1, CHCl3:MeOH=9:1)
Properties (reference)
Melting Point 247 °C(dec.)
Specific Rotation -111° (C=1,CHCl3:MeOH=9:1)
Maximum Absorption Wavelength 283(MeOH) nm
Solubility in water Insoluble
Degree of solubility in water 5.9 mg/l   25 °C
GHS
Pictogram Pictogram
Signal Word Danger
Hazard Statements H361 : Suspected of damaging fertility or the unborn child.
H371 : May cause damage to organs.
H372 : Causes damage to organs through prolonged or repeated exposure.
H341 : Suspected of causing genetic defects.
H350 : May cause cancer.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P260 : Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor.
Related Laws:
EC Number 249-831-2
RTECS# KC0180000
Transport Information:
HS Number 2938909090
Application
Teniposide: An Inhibitor of Topoisomerase II

Teniposide (VM26) and etoposide (VP16-213) [E0675] are semisynthetic derivatives of podophyllotoxin [P1771], an alkaloid. Teniposide and teniposide are an inhibitor of topoisomerase II such as doxorubicin [D4193], daunorubicin [D4532]. Topoisomerase II is an enzyme essential for DNA replication, chromosome condensation and chromosome segregation. Topoisomerase II inhibitors are potent inducers of double strand breaks in DNA, and can cause arrest in the cell cycle at the G2 stage. Therefore, topoisomerase II inhibitors are the most widely used anti-cancer agents. Teniposide is used for the treatment of acute lymphocytic leukemia (ALL). (The product is for research purpose only.)

References


PubMed Literature


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