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CAS RN: 106685-40-9 | Product Number: A2549
Adapalene
									 
							Purity: >98.0%(T)(HPLC)
Synonyms:
						
						- 6-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoic Acid
 
Product Documents:
                    
				
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| Product Number | A2549 | 
Purity / Analysis Method  
                                     | 
                                    >98.0%(T)(HPLC) | 
| Molecular Formula / Molecular Weight | C__2__8H__2__8O__3 = 412.53 | 
| Physical State (20 deg.C) | Solid | 
Storage Temperature  
                                     | 
                                    Refrigerated (0-10°C) | 
| Condition to Avoid | Heat Sensitive | 
Packaging and Container  
                                     | 
                                    1G-Glass Bottle with Plastic Insert (View image), 200MG-Glass Bottle with Plastic Insert (View image) | 
| CAS RN | 106685-40-9 | 
| Reaxys Registry Number | 7393980 | 
| PubChem Substance ID | 172088913 | 
| Merck Index (14) | 150 | 
| MDL Number | MFCD03106112  | 
                                
Specifications
		  | Appearance | White to Light yellow powder to crystal | 
| Purity(HPLC) | min. 98.0 area% | 
| Purity(Neutralization titration) | min. 98.0 % | 
		Properties (reference)
	| Melting Point | 324 °C | 
 
						 GHS
						 | Pictogram | 
										   		 
								    			 | 
								   	 
| Signal Word | Warning | 
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. | 
                                
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up.  | 
                                
 
								 Related Laws: 
							   | RTECS# | QJ1987000 | 
 
						Transport Information:
							| H.S.code* | 2918.99-000 | 
			Application
		
			Studies on Retinoic Acid Receptors (RARs)
		
		References
- Synthesis, Structure-Affinity Relationships, and Biological Activities of Ligands Binding to Retinoic Acid Receptor Subtypes
 - Recent developments in receptor-selective retinoids
 - In vitro modulation of TLR-2, CD1d and IL-10 by adapalene on normal human skin and acne inflammatory lesions
 - A review of the use of adapalene for the treatment of acne vulgaris				     				 
- S. Piskin, E. Uzunali, Ther. Clin. Risk Manage. 2007, 3, 621.
 
 - Site-specific drug delivery to pilosebaceous structures using polymeric microspheres
 
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