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CAS RN: 36951-72-1 | Product Number: A5014
TMPyP [Ultra-high sensitive spectrophotometric reagent for Cu, Mg] [For the simultaneous determination of metals by HPLC]
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Purity: >98.0%(N)
Synonyms:
- α,β,γ,δ-Tetrakis(1-methylpyridinium-4-yl)porphyrin p-Toluenesulfonate
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 100MG |
$49.00
|
2 | 11 | It can be shipped in about 2 weeks after ordering | |
| 1G |
$279.00
|
3 | 26 | It can be shipped in about 2 weeks after ordering |
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* The storage conditions are subject to change without notice.
| Product Number | A5014 |
Purity / Analysis Method 
|
>98.0%(N) |
| Molecular Formula / Molecular Weight | C__7__2H__6__6N__8O__1__2S__4 = 1,363.60 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Hygroscopic |
| Packaging and Container
|
100MG-Glass Bottle with Plastic Insert (View image), 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 36951-72-1 |
| Reaxys Registry Number | 5237096 |
| PubChem Substance ID | 87563108 |
| MDL Number | MFCD00013468 |
Specifications
| Appearance | Dark red to Dark purple to Dark blue powder to crystal |
| Purity(HPLC) | min. 92.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Molar extinction coefficient | min. 280000(1mol/L HCl, 443.0 to 447.0 nm) |
| Suitability test | to pass test |
Properties (reference)
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| H.S.code* | 2933.99-000 |
Application
TMPyP: A Cationic Porphyrin as a G-quadruplex Stabilizer and a Singlet Oxygen Producer
TMPyP (other name: TMPyP4 tosylate) is a cationic porphyrin with a strong affinity for DNA and a high yield of singlet oxygen generation upon light activation. TMPyP intercalates into and stabilizes guanine quadruplexes (G4s), which are non-Watson-Crick four-stranded nucleic acid structures held together by non-canonical G-G base tetrads. In this way, TMPyP inhibits telomerase activity, thereby blocking the growth and proliferation of cancer cells.1,3) TMPyP also interacts with HSV-1 G4s and inhibits polymerase progression in vitro; in infected cells.2,3) In addition, TMPyP is used as a photosensitizer for photodynamic therapy (PDT).3,4) (The product is for research use only.)
References
- 1) Interactions of TMPyP4 and TMPyP2 with Quadruplex DNA. Structural Basis for the Differential Effects on Telomerase Inhibition
- 2) Antiviral Activity of the G-Quadruplex Ligand TMPyP4 against Herpes Simplex Virus-1
- 3) Multimodal use of the porphyrin TMPyP: From cancer therapy to antimicrobial applications (a review)
- 4) TMPyP4 promotes cancer cell migration at low doses, but induces cell death at high doses
PubMed Literature
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