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CAS RN: 18303-04-3 | Product Number: B1648

N-(tert-Butoxycarbonyl)-p-toluenesulfonamide


Purity: >98.0%(T)(HPLC)
Synonyms:
  • N-Boc-p-toluenesulfonamide
Documents:
10G
$77.00
≥20  Contact Us
25G
$141.00
≥20  2  

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* The storage conditions are subject to change without notice.


Product Number B1648
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__2H__1__7NO__4S = 271.33  
Physical State (20 deg.C) Solid
CAS RN 18303-04-3
Reaxys Registry Number 2858665
PubChem Substance ID 87564549
MDL Number

MFCD00134267

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %
Properties (reference)
Melting Point 123 °C
GHS
Related Laws:
Transport Information:
H.S.code* 2935.90-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Application
Sulfonamide Effective for the Introduction of Amino group

Experimental procedure: To a solution of PPh3 (6.23 g, 23.8 mmol) in THF (56 mL) under an atmosphere of nitrogen at 0 °C is added DIAD (3.85 g, 23.8 mmol). The reaction is stirred at 0 °C for 30 min before N-(tert-butoxycarbonyl)-p-toluenesulfonamide (5.37 g, 20.0 mmol) is added. The mixture is allowed to stir at 0 °C for 5 min followed by the addition of 1 (3.11 g, 19.8 mmol). The reaction is stirred at room temperature for 2.5 h before being concentrated under reduced pressure to give a crude oil. The oil is purified by flash column chromatography (silica gel, ethyl acetate:hexanes = 1:20) to generate 2 (7.54 g, 18.4 mmol, 93%) as orange oil.

References


Application
Sulfonamide under Mitsunobu Reaction

References


PubMed Literature


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