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CAS RN: 980-71-2 | Product Number: B5167
Brompheniramine Maleate
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Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
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| 25G |
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| Product Number | B5167 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__1__9BrN__2·C__4H__4O__4 = 435.32 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 980-71-2 |
| Related CAS RN
|
86-22-6 |
| Reaxys Registry Number | 4117058 |
| PubChem Substance ID | 354333694 |
| Merck Index (14) | 1443 |
| MDL Number | MFCD00057367 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 134.0 to 138.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 136 °C |
| Maximum Absorption Wavelength | 261 nm |
| Solubility in water | Soluble |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | US4025000 |
Transport Information:
| H.S.code* | 2933.39-000 |
Application
Brompheniramine Maleate: A First Generation Histamine H1 Receptor Antagonist
Brompheniramine maleate is a first generation histamine H1 receptor antagonist. Brompheniramine binds to a G protein-coupled form of the receptor and promotes a G protein-coupled inactive state of the H1 receptor that interferes with the Gq/11-mediated signaling. Brompheniramine permeates the blood-brain barrier causing drowsiness. Brompheniramine also has anticholinergic properties. For reference, we also have related first generation histamine H1 receptor antagonists, such as pheniramine maleate [P2271] (H instead of Br), chlorpheniramine maleate [C0873] (Cl instead of Br) and pyrilamine maleate [P2369]. (The product is for research purpose only.)
References
- Effect of pheniramine, chlorpheniramine and brompheniramine on stimulated blood platelets: structure-activity relationships
- Anticholinergic properties of brompheniramine, chlorpheniramine, and atropine in human nasal mucosa in vitro.
- Separation of brompheniramine enantiomers by capillary electrophoresis and study of chiral recognition mechanisms of cyclodextrins using NMR-spectroscopy, UV spectrometry, electrospray ionization mass spectrometry and X-ray crystallography
- Analysis of pharmaceutical preparations containing antihistamine drugs by micellar liquid chromatography
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