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CAS RN: 7689-03-4 | Product Number: C1495
(S)-(+)-Camptothecin
×
Purity: >97.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 100MG |
$27.00
|
0 | 9 | Contact Us | |
| 1G |
$157.00
|
16 | 6 | Contact Us |
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to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
| Product Number | C1495 |
Purity / Analysis Method 
|
>97.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__1__6N__2O__4 = 348.36 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 7689-03-4 |
| Reaxys Registry Number | 6075662 |
| PubChem Substance ID | 87566492 |
| Merck Index (14) | 1735 |
| MDL Number | MFCD00081076 |
Specifications
| Appearance | White to Yellow powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Nonaqueous Titration) | min. 95.0 % |
| Specific rotation [a]20/D | +37.0 to +42.0 deg(C=0.4, CHCl3:MeOHl=8:2) |
| NMR | confirm to structure |
Properties (reference)
| Specific Rotation | 40° (C=0.4,CHCl3:MeOH=8:2) |
| Solubility (soluble in) | Chloroform, Methanol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | UQ0492000 |
Transport Information:
| UN Number | UN1544 |
| Class | 6.1 |
| Packing Group | III |
| H.S.code* | 2939.79-000 |
Application
Adeno-associated virus vector transduction enhancer
Camptothecin increases transduction by adeno-associated virus (AAV) vectors.1)
References
- 1) DNA synthesis and topoisomerase inhibitors increase transduction by adeno-associated virus vectors
Application
Camptothecin: The First Identified Topoisomerase-I Inhibitor
Camptothecin (CPT), a plant alkaloid with antitumor activity, was first isolated by Wall et al. in 1966 from the Chinese tree, Camptotheca acuminate. CPT shows strong anticancer activity against a wide range of experimental tumors, but also low water solubility and high toxicity (myelosuppression and hemorrhagic cystitis). Because of these disadvantages, various CPT derivatives have been discovered such as irinotecan hydrochloride [I0714] and topotecan. Camptotecin and its derivatives interfere with DNA synthesis by inhibiting the enzyme topoisomerase-I. In order to prevent and correct of topological problems caused by the DNA double helix, topoisomerase-I catalyzes the relaxation of negatively supercoiled DNA, the knotting and unknotting DNA and the linking complementary rings of single-stranded DNA into double-stranded rings. Then the inhibition action induces breaks in single strand DNA. Eventually, this leads to double-strand DNA breaks and apoptosis or cell death. (The product is for research purpose only.)
References
- Plant antitumor agents. I. Isolation and structure of camtothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminata
- Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I
- Synthesis of water-soluble (aminoalkyl)camptothecin analogs: inhibition of topoisomerase I and antitumor activity
- Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme (a review)
- Camptothecin: current perspectives (a review)
- Topoisomerase I inhibitors: camptothecins and beyond (a review)
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