Maximum quantity allowed is 999
Please select the quantity
CAS RN: 2259-96-3 | Product Number: C3392
Cyclothiazide (mixture of isomers)
×
Purity: >95.0%(HPLC)
Synonyms:
- 6-Chloro-3,4-dihydro-3-(2-norbornen-5-yl)-2H-1,2-4-benzothiadiazine-7-sulfonamide 1,1-Dioxide (mixture of isomers)
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 25MG |
$110.00
|
4 | 0 | It can be shipped in about 2 weeks after ordering | |
| 100MG |
$308.00
|
3 | 0 | It can be shipped in about 2 weeks after ordering |
* Please contact our distributors or
TCI
to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
| Product Number | C3392 |
Purity / Analysis Method 
|
>95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__4H__1__6ClN__3O__4S__2 = 389.87 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
25MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 2259-96-3 |
| Reaxys Registry Number | 722843 |
| PubChem Substance ID | 354335513 |
| Merck Index (14) | 2754 |
| MDL Number | MFCD00210192 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 %(total of isomer) |
| Elemental analysis(Nitrogen) | 10.20 to 11.20 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 234 °C |
| Maximum Absorption Wavelength | 273 nm |
GHS
Related Laws:
| RTECS# | DK9610000 |
Transport Information:
| H.S.code* | 2935.90-000 |
Application
Cyclothiazide: A Benzothiadiazide Antagonist of AMPA Receptors
α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (also known as AMPA receptors) are a class of ionotropic glutamate receptors, and major players in mediating basal synaptic transmission and synaptic plasticity in the mammalian CNS. AMPA-receptor modulation could be a way of adjusting the excitatory–inhibitory balance. Therefore, AMPA receptors are emerging as a new target for epilepsy, depression, etc. Cyclothiazide has been reported as a benzothiadiazide antagonist of AMPA receptors, and a promising tool for analysis of allosteric regulatory mechanisms at AMPA receptors. (The product is for research purpose only.)
References
- Benzothiadiazides inhibit rapid glutamate receptor desensitization and enhance glutamatergic synaptic currents
- Cyclothiazide differentially modulates desensitization of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor splice variants
- Mechanism of glutamate receptor desensitization
- AMPA receptor potentiators: application for depression and parkinson's disease (a review)
- Cyclothiazide (a review of the physical properties, methods of analysis, synthesis and stability of cyclothiazide)
- Preparative isolation of the eutomer of cyclothiazide by high-performance liquid chromatography on a cellulose-derived chiral stationary phase with toluene-acetone as the mobile phase
PubMed Literature
Product Articles
Product Documents (Note: Some products will not have analytical charts available.)
Enter TCI Product Number
Enter KISHIDA Product Number
4-5 alphanumeric characters before the hyphen
7 alphanumeric characters
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
• The requested SDS is not available.
Specifications
The requested specifications are not available.
Please Contact Us for more information.
The requested specifications are not available.
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Incorrect Lot Number. Please input only the 7 alphanumeric characters.
• Please check that the lot number you have entered is correct. It is 4-5 alphanumeric characters before the hyphen. In particular, please check O (letter) or 0 (number) and I (letter) or 1 (number).
• If your information is correct and you are still not able to view the requested certificates, Please Contact Us for more information.
• Please check that the lot number you have entered is correct. It is 7 alphanumeric characters. In particular, please check O (letter) or 0 (number) and I (letter) or 1 (number).
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Incorrect Lot Number. Please input only the 7 alphanumeric characters.
The requested analytical chart is not available. Sorry for the inconvenience.