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CAS RN: 288383-20-0 | Product Number: C3918
Cediranib
×
Purity: >95.0%(T)(HPLC)
Synonyms:
- AZD 2171
- 4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 5MG |
$91.00
|
35 | 0 | Contact Us |
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| Product Number | C3918 |
Purity / Analysis Method 
|
>95.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__5H__2__7FN__4O__3 = 450.51 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 288383-20-0 |
| Reaxys Registry Number | 11404252 |
| MDL Number | MFCD09954115 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Nonaqueous Titration) | min. 95.0 % |
| NMR | confirm to structure |
Properties (reference)
| Maximum Absorption Wavelength | 530 nm (MeOH) |
GHS
Related Laws:
| RTECS# | VA1424500 |
Transport Information:
| H.S.code* | 2933.59-000 |
Application
Cediranib: A VEGF Receptor Tyrosine Kinase Inhibitor
Receptors for VEGF (vascular endothelial growth factor-A) play a central role in vasculogenesis and angiogenesis and are therefore targets for cancer therapy. Cediranib (AZD2171) and its water-soluble maleate [R0277] are VEGF receptor tyrosine kinase inhibitors used in cancer research. (The product is for research use only.)
References
- AZD2171 : A highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer
- The tyrosine kinase inhibitor cediranib for non-small cell lung cancer and other thoracic malignancies (a review)
- Cediranib , a pan-VEGFR inhibitor, and olaparib, a PARP inhibitor, in combination therapy for high grade serous ovarian cancer
- Solubility and stability of cediranib maleate
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