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CAS RN: 2127-03-9 | Product Number: D1114

2,2'-Dipyridyl Disulfide [for Peptide Synthesis]

Purity: >98.0%(GC)(T)
  • 2,2'-Dithiodipyridine
≥20  6  
16   4  
13   12  

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Product Number D1114
Purity / Analysis Method >98.0%(GC)(T)
Molecular Formula / Molecular Weight C__1__0H__8N__2S__2 = 220.31  
Physical State (20 deg.C) Solid
Store Under Inert Gas Store under inert gas
Condition to Avoid Air Sensitive
CAS RN 2127-03-9
Reaxys Registry Number 154629
PubChem Substance ID 87567675
SDBS (AIST Spectral DB) 12066
MDL Number


Appearance White to Almost white powder to crystal
Purity(GC) min. 98.0 %
Purity(Nonaqueous Titration) min. 98.0 %
Melting point 57.0 to 60.0 °C
Solubility in Methanol almost transparency
Properties (reference)
Melting Point 58 °C
Solubility in water Soluble
Solubility (soluble in) Ethanol,Methanol,Acetone
Pictogram Pictogram
Signal Word Warning
Hazard Statements H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P302 + P352 : IF ON SKIN: Wash with plenty of water.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
Related Laws:
Transport Information:
H.S.code* 2933.39-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
TCI Practical Example: β-Lactamization through Condensation Reaction

Used Chemicals


To a solution of 3-amino-3-phenylpropionic acid (463 mg, 2.80 mmol) and triphenylphosphine (881 mg, 3.36 mmol) in acetonitrile (28 mL) was added 2,2'-dipyridyl disulfide (740 mg, 3.36 mmol) and the mixture was stirred at reflux for 3 hours. The solvent was removed under reduced pressure and the residue was purified by column chromatography (1:1 diethyl ether / dichloromethane on SiO2), giving white solid (250 mg, 56%).

Experimenter’s Comments

Analytical Data(4-Phenyl-2-azetidinone)

1H NMR (400 MHz, CDCl3); δ 7.27 – 7.38 (m, 5H), 6.47 (br s, 1H), 4.70 (dd, 1H, J = 2.4, 5.2 Hz), 3.41 (ddd, 1H, J = 2.4, 5.2, 14.8 Hz), 2.84 (dd, 1H, J = 2.0, 14.8 Hz).

13C NMR (101 MHz, CDCl3); δ 168.2, 140.1, 128.8, 128.2, 125.6, 50.3, 47.9.

Lead Reference

Other References

PubMed Literature

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