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CAS RN: 993-12-4 | Product Number: D2159

Dimethylthiophosphinoyl Chloride

Purity: >97.0%(GC)
  • Chlorodimethylphosphine Sulfide
  • Dimethylphosphinothioyl Chloride
3   4  
15   3  

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Product Number D2159
Purity / Analysis Method >97.0%(GC)
Molecular Formula / Molecular Weight C__2H__6ClPS = 128.55  
Physical State (20 deg.C) Liquid
Storage Temperature 0-10°C
Store Under Inert Gas Store under inert gas
Condition to Avoid Moisture Sensitive,Heat Sensitive
CAS RN 993-12-4
Reaxys Registry Number 906761
PubChem Substance ID 87568600
MDL Number


Appearance Colorless to Almost colorless clear liquid
Purity(GC) min. 97.0 %
Properties (reference)
Boiling Point 78 °C/15 mmHg
Specific Gravity (20/20) 1.22
Refractive Index 1.54
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled.
H314 : Causes severe skin burns and eye damage.
H290 : May be corrosive to metals.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray.
P270 : Do not eat, drink or smoke when using this product.
P234 : Keep only in original container.
P271 : Use only outdoors or in a well-ventilated area.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P390 : Absorb spillage to prevent material damage.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower.
P301 + P330 + P331 : IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor.
P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor.
P406 : Store in corrosive resistant container with a resistant inner liner.
P405 : Store locked up.
Related Laws:
Transport Information:
UN Number UN3265
Class 8
Packing Group II
H.S.code* 2931.59-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
A Condensing Reagent for the Peptide Synthesis in Alcohol Solvents

Experimental procedure1): A solution of Cbz-Asn-OH (79.8 mg, 0.3 mmol) and triethylamine (41.8 µL, 0.3 mmol) in methanol (2.6 mL) is cooled to -20 °C, and treated with a solution of Dimethylthiophosphinoyl Chloride (Mpt-Cl, 38 mg, 0.3 mmol) in methanol (0.9 mL), and the mixture stirred for 20 min. The solution is added to a solution of the tetrapeptide (1, 133.3 mg, 0.3 mmol) and triethylamine (41.8 µL, 0.3 mmol) in methanol (7.0 mL) and water (3.0 mL) at -20 °C. After the mixture has been stirred for 40 minutes the Cbz-Asn-OMpt solution and triethylamine (0.3 mmol each) are added and the stirring continued at -20 °C for 2 h and at 0 °C for 48 h. The precipitate is filtered and washed with chloroform, ethanol, water, and ether, and dried to give the pentapeptide (2, 173.7 mg, 84 %).

Peptide Synthesis, Glycosylation


PubMed Literature

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