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CAS RN: 188945-41-7 | Product Number: D2548

Ethyl Di-o-tolylphosphonoacetate [Horner-Emmons Reagent]


Purity: >95.0%(GC)
Synonyms:
  • Di-o-tolylphosphonoacetic Acid Ethyl Ester
Documents:
1G
$237.00
11   ≥20 

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Product Number D2548
Purity / Analysis Method >95.0%(GC)
Molecular Formula / Molecular Weight C__1__8H__2__1O__5P = 348.33  
Physical State (20 deg.C) Liquid
CAS RN 188945-41-7
Reaxys Registry Number 7720487
PubChem Substance ID 87568970
MDL Number

MFCD01321166

Specifications
Appearance Colorless to Yellow to Orange clear liquid
Purity(GC) min. 95.0 %
Properties (reference)
Boiling Point 240 °C/3 mmHg
Specific Gravity (20/20) 1.19
Refractive Index 1.53
GHS
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Transport Information:
H.S.code* 2931.39-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Application
Z-selective Horner-Emmons Reagents

Typical Procedure: To a solution of ethyl (di-o- tolylphosphono)acetate (0.50 mmol) in THF (2 mL) is added NaH (280 mg, 0.70 mmol) at 0 ℃. 15 min later, aldehyde (0.55mmol) in THF (0.50 mL) is added at -78 ℃, and the resulting mixture is stirred at -20 ℃ over 1-2 hour. The reaction is quenched with saturated NH4Cl, and the mixture is extracted with AcOEt (10 mL×3). The combined extracts are washed with water (15 mL×2) followed by brine, dried (MgSO4) and concentrated. The isomers are separated by flash chromatography.

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