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CAS RN: 71939-50-9 | Product Number: D3793
Dihydroartemisinin
×
Purity: >98.0%(HPLC)
Synonyms:
Product Documents:
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|---|---|---|---|---|---|
| 1G |
$95.00
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| 5G |
$274.00
|
26 | 0 | It can be shipped in about 2 months after ordering |
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| Product Number | D3793 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__5H__2__4O__5 = 284.35 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 71939-50-9 |
| Reaxys Registry Number | 5813803 |
| PubChem Substance ID | 87561556 |
| SDBS (AIST Spectral DB) | 52709 |
| Merck Index (14) | 817 |
| MDL Number | MFCD00274495 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC)(CAD) | min. 98.0 %(Anomeric total) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 153 °C(dec.) |
GHS
Related Laws:
| RTECS# | KD4165550 |
Transport Information:
| H.S.code* | 2932.99-000 |
Application
Dihydroartemisinin: An Active Metabolite of Antimalaria Artesunate
Dihydroartemisinin is an active metabolite of artesunate [A2191] which is a semi-synthetic derivative of artemisinin [A2118]. Dihydroartemisinin and its analogs have high efficacy against Plasmodium falciparum in the blood stages of the disease. The exact mechanism of action is still not clear, while the endoperoxide (O-O) subunit of the trioxane ring is critical for antimalarial activity. Several lines of evidence indicate that the O-O bond is easily broken by Fe2+, generating a number of reactive radicals oxidatively damage parasite. In clinical, dihydroartemisinin is often used as a combination agent with a partner agent which has a long half-life, such as piperaquine. In addition, after 2000’s, the anti-tumor activities of dihydroartemisinin have been reported. (The product is for research purpose only.)
References
- Review of the clinical pharmacokinetics of artesunate and its active metabolite dihydroartemisinin following intravenous, intramuscular, oral or rectal administration
- Efficacy and safety of dihydroartemisinin-piperaquine
- Dihydroartemisinin is an inhibitor of ovarian cancer cell growth
- Dihydroartemisinin induces apoptosis and sensitizes human ovarian cancer cells to carboplatin therapy
- Dihydroartemisinin inactivates NF-κB and potentiates the anti-tumor effect of gemcitabine on pancreatic cancer both in vitro and in vivo
- Development and validation of a high-performance liquid chromatography-mass spectroscopy assay for determination of artesunate and dihydroartemisinin in human plasma
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