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CAS RN: 24390-14-5 | Product Number: D4116
Doxycycline Hyclate
×
Purity: >97.0%(HPLC)
Synonyms:
- Doxycycline Hydrochloride Hemiethanolate Hemihydrate
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 5G |
$90.00
|
9 | 18 | It can be shipped in about 2 weeks after ordering | |
| 25G |
$307.00
|
16 | ≥100 | Contact Us |
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* The storage conditions are subject to change without notice.
| Product Number | D4116 |
Purity / Analysis Method 
|
>97.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__2__4N__2O__8·^^1/__2C__2H__6O·HCl·^^1/__2H__2O = 512.94 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 24390-14-5 |
| Related CAS RN
|
10592-13-9&564-25-0 |
| PubChem Substance ID | 172089114 |
| Merck Index (14) | 3440 |
| MDL Number | MFCD07357237 |
Specifications
| Appearance | Light yellow to Amber to Dark green powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Nonaqueous Titration) | min. 95.0 % |
| Specific rotation [a]20/D | -100 to -107 deg(C=1, 0.01mol/L HCl(MeOH)) |
| Water | 1.4 to 2.8 % |
| Ethanol(NMR) | 4.3 to 6.0 % |
Properties (reference)
| Specific Rotation | -104° (C=1,0.01mol/L HCl(MeOH)) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
Transport Information:
| H.S.code* | 2941.30-000 |
Application
Gingipain inhibitor
Doxycycline has been reported to inhibit gingipains, RgpB, HRgpA, (IC50 : about 3 μM, respectively) and Kgp (IC50 : about 20 μM) from Porphyromonas gingivalis.1) The Ki value of the compound to RgpB is 54 μM.
(The product is for research purpose only.)
(The product is for research purpose only.)
Reference
- 1) Inhibition of Trypsin-Like Cysteine Proteinases (Gingipains) from Porphyromonas gingivalis by Tetracycline and Its Analogues
- Doxycycline revisited
- Development and evaluation of novel biodegradable microspheres based on poly(D,L-lactide-co-glycolide) and poly(ε-caprolactone) for controlled delivery of doxycycline in the treatment of human periodontal pocket: In vitro and in vivo studies
- Subantimicrobial dose doxycycline as adjunctive treatment for periodontitis.
- Subantimicrobial dose doxycycline as an adjunct to scaling and root planing: Post-treatment effects
- Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice
- Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity
- piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells
- Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector
- Transcriptional activation by tetracyclines in mammalian cells
- M. Gossen, S. Freundlieb, G. Bender, G. Muller, W. Hillen, H. Bujard, Science 1995, 268, 1766.
Application
Studies on the Antibacterial Activity of Doxycycline
References
Application
Applications of Doxycycline to Biogenetics Studies
References
PubMed Literature
Documents
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