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CAS RN: 23674-86-4 | Product Number: D5579

Difluprednate


Purity: >98.0%(HPLC)
Synonyms:
  • 6α,9α-Difluoroprednisolone-21-acetate-17-butyrate
Documents:
50MG
$113.00
6   Contact Us
250MG
$435.00
5   1  

* Please contact our distributors or TCI to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.


Product Number D5579
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__2__7H__3__4F__2O__7 = 508.56  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Heat Sensitive
Packaging and Container 50MG-Glass Bottle with Plastic Insert (View image)
CAS RN 23674-86-4
Reaxys Registry Number 2068619
Merck Index (14) 3152
MDL Number

MFCD00214273

Specifications
Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 98.0 area%
Melting point 191.0 to 195.0 °C
Properties (reference)
Melting Point 193 °C
Specific Rotation 31° (C=2,Dioxane)
Solubility in water Insoluble
Degree of solubility in water 0.008 g/l  
Solubility (soluble in) Ethanol,Methanol,Chloroform
Solubility (very slightly) Diethyl ether
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H361 : Suspected of damaging fertility or the unborn child.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P405 : Store locked up.
Related Laws:
RTECS# TU3831500
Transport Information:
H.S.code* 2937.29-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Application
Difluprednate: A Potent Topical Corticosteroid

Difluprednate (DFBA) is a potent topical corticosteroid owing to its high affinity for glucocorticoid receptors. Actually, it is a prodrug that is converted to its active metabolite difluoroprednisolone butyrate (DFB) by deacetylation after penetration. Corticosteroids are commonly used to control inflammation, and difluprednate ophthalmic emulsion is commonly used for the treatment of anterior uveitis. There is no generally accepted explanation for the mechanism of action of corticosteroids. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory anti-inflammatory proteins, collectively called lipocortins, and inhibiting the release of arachidonic acid from membrane phospholipids by phospholipase A2. (The product is for research purpose only.)

References


Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
C of A & Other Certificates
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Analytical Charts
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