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CAS RN: 29110-48-3 | Product Number: G0414

Guanfacine Hydrochloride


Purity: >98.0%(T)(HPLC)
Synonyms:
  • N-(Aminoiminomethyl)-2,6-dichlorobenzeneacetamide Hydrochloride
  • N-Amidino-2-(2,6-dichlorophenyl)acetamide Hydrochloride
Documents:
100MG
$99.00
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1G
$634.00
10   1  

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Product Number G0414
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__9H__9Cl__2N__3O·HCl = 282.55  
Physical State (20 deg.C) Solid
Packaging and Container 100MG-Glass Bottle with Plastic Insert (View image)
CAS RN 29110-48-3
Related CAS RN 29110-47-2
Reaxys Registry Number 6019938
PubChem Substance ID 253662104
Merck Index (14) 4561
MDL Number

MFCD00798230

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Melting point 211.0 to 215.0 °C
Properties (reference)
Melting Point 213 °C
GHS
Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 : Toxic if swallowed.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P405 : Store locked up.
Related Laws:
RTECS# CY1481000
Transport Information:
UN Number UN2811
Class 6.1
Packing Group III
H.S.code* 2925.29-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Application
Guanfacine Hydrochloride: A Centrally Acting α2A-Adrenoceptor Agonist

Guanfacine hydrochloride, a phenylacetyl-guanidine derivative, is a centrally acting α2A-adrenoceptor agonist with a mechanism of antihypertensive action similar to that of clonidine [D1353]. It reduces blood pressure in human with essential hypertension (EH) at least as effectively as clonidine or methyldopa [D1817]. Recent research has found that guanfacine can improve prefrontal cortex (PFC) function by strengthening PFC network connections via inhibition of cAMP-potassium channel signaling in postsynaptic spines. Guanfacine is now being used to treat a variety of PFC cognitive disorders, including attention deficit/hyperactivity disorder (ADHD). (The product is for research purpose only.)

References


PubMed Literature


TCIMAIL
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