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CAS RN: 56974-61-9 | Product Number: G0464
Gabexate Mesylate
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Purity: >97.0%(N)
Synonyms:
- 4-[[6-[(Aminoiminomethyl)amino]-1-oxohexyl]oxy]benzoic Acid Ethyl Ester Mesylate
- Gabexate Methanesulfonate
Product Documents:
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| 1G |
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Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | G0464 |
| Purity / Analysis Method | >97.0%(N) |
| Molecular Formula / Molecular Weight | C__1__6H__2__3N__3O__4·CH__4O__3S = 417.48 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 56974-61-9 |
| Related CAS RN | 39492-01-8 |
| Reaxys Registry Number | 5702026 |
| PubChem Substance ID | 253660880 |
| Merck Index (14) | 4320 |
| MDL Number | MFCD00210299 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 94.0 area% |
| Purity(with Total Nitrogen) | min. 97.0 % |
| Melting point | 89.0 to 93.0 °C |
Properties (reference)
| Melting Point | 91 °C |
| Solubility (soluble in) | Methanol |
| Solubility (slightly sol. in) | Acetone |
| Solubility (insoluble in) | Ether |
GHS
Related Laws:
| RTECS# | DG2800800 |
Transport Information:
| H.S.code* | 2925.29-000 |
Application
Gabexate Mesylate: A Synthetic Non-Peptide Protease Inhibitor
Gabexate mesylate is a synthetic non-peptide protease inhibitor. It inhibits trypsin, kallikrein, thrombin, plasmin, C1 esterase, and etc. Gabexate mesylate inhibit thrombin and activated factor X, being independent of plasma antithrombin level. Gabexate mesylate is used as anticoagulants for the treatment of disseminated intravascular coagulation (DIC). (The product is for research purpose only.)
References
- FOY: [ethyl-p-(6-guanidinohexanoyloxy) benzoate] methanesulfonate as a serine proteinase inhibitor. I. Inhibition of thrombin and factor Xa in vitro
- Gabexate mesylate and pivmecillinam hydrochloride (a review)
- D. F. Weetman, Drugs Today 1978, 14, 411.
- Competitive inhibition of swine kidney copper amine oxidase by drugs: amiloride, clonidine, and gabexate mesylate
- Gabexate mesilate, a synthetic protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-α producation by inhibiting activation of both nuclear factor-κB and activator protein-1 in human monocytes
- Gabexate mesilate inhibits colon cancer growth, invasion, and metastasis by reducing matrix metalloproteinases and angiogenesis
PubMed Literature
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