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CAS RN: 21715-90-2 | Product Number: H0528

N-Hydroxy-5-norbornene-2,3-dicarboximide [for Peptide Synthesis]


Purity: >99.0%(T)
Synonyms:
Documents:
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Product Number H0528
Purity / Analysis Method >99.0%(T)
Molecular Formula / Molecular Weight C__9H__9NO__3 = 179.18 
Physical State (20 deg.C) Solid
CAS RN 21715-90-2
Reaxys Registry Number 181264
PubChem Substance ID 87570917
SDBS (AIST Spectral DB) 12651
MDL Number

MFCD00167583

Specifications
Appearance White to Almost white powder to crystal
Purity(Neutralization titration) min. 99.0 %
Melting point 167.0 to 171.0 °C
Solubility in Water almost transparency
Properties (reference)
Melting Point 167 °C
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P302 + P352 : IF ON SKIN: Wash with plenty of water.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
Related Laws:
Transport Information:
H.S.code* 2928.00-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Application
An Efficient Additive for Condensation Reactions

Experimental procedure: to a solution of 1 (1 mmol) in anhydrous DMF (10 mL) is added N-Hydroxy-5-norbornene-2,3-dicarboximide (1.1 mmol) and DIC (1.1 mmol) in one portion. Reaction mixture is stirred for additional 5 min at 0 °C and then L-ProNH2(2, 1 mmol) is added. The reaction is stirred for additional 36 h at 4 °C. Solvent is evaporated under reduced pressure and the crude product is purified by column chromatography using MeOH/CH2Cl2 (15:85) as eluant to afford 3 as a white solid in 77% yield.

References


PubMed Literature


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