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CAS RN: 3420-72-2 | Product Number: H1571
Flavokawain A
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Purity: >98.0%(GC)
Synonyms:
- 2'-Hydroxy-4,4',6'-trimethoxychalcone
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
$61.00
|
15 | 2 | It can be shipped in about 2 weeks after ordering | |
| 5G |
$216.00
|
2 | 0 | It can be shipped in about 2 weeks after ordering |
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* The storage conditions are subject to change without notice.
| Product Number | H1571 |
Purity / Analysis Method 
|
>98.0%(GC) |
| Molecular Formula / Molecular Weight | C__1__8H__1__8O__5 = 314.34 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 3420-72-2 |
| Related CAS RN
|
37951-13-6 |
| Reaxys Registry Number | 2009865 |
| PubChem Substance ID | 354334221 |
| MDL Number | MFCD00017174 |
Specifications
| Appearance | Light yellow to Brown powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 112.0 to 116.0 °C |
Properties (reference)
| Melting Point | 114 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| H.S.code* | 2914.50-000 |
Application
Flavokawain A: An Apoptosis Inducing Agent
Flavokawain A, a major 2'-hydroxy-chalcone derived from kava plant extract, has recently demonstrated promising anti-cancer and anti-inflammatory activities. Some studies have shown that flavokawain A decreases cyclin-dependent kinase-2 (CDK2) inducing G2/M arrest in vitro, and then it has antiproliferative and apoptotic effects in cancer cells. In addition, it has been reported that flavokawain A suppresses expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). (The product is for research purpose only.)
References
- Flavokawain A, a Novel Chalcone from Kava Extract, Induces Apoptosis in Bladder Cancer Cells by Involvement of Bax Protein-Dependent and Mitochondria-Dependent Apoptotic Pathway and Suppresses Tumor Growth in Mice
- Natural and synthetic 2'-hydroxy-chalcones and aurones: Synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity
- Effects of the Kava chalcone flavokawain A differ in bladder cancer cells with wild-type versus mutant p53
- Suppression of iNOS and COX-2 expression by flavokawain A via blockade of NF-κB and AP-1 activation in RAW 264.7 macrophages
- HPLC analysis of flavokavins and kavapyrones from Piper methysticum Forst.
- Detection of flavokavins (A, B, C) in cultivars of kava (Piper methysticum) using high performance thin layer chromatography (HPTLC)
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