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CAS RN: 155558-32-0 | Product Number: H1745
Hydroxyfasudil Hydrochloride
×
Purity: >98.0%(HPLC)
Synonyms:
- 5-[(1,4-Diazepan-1-yl)sulfonyl]isoquinolin-1(2H)-one Hydrochloride
- HA 1100 Hydrochloride
- 1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine Hydrochloride
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
$155.00
|
9 | 3 | It can be shipped in about 2 weeks after ordering | |
| 50MG |
$505.00
|
10 | 6 | It can be shipped in about 2 weeks after ordering |
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to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
| Product Number | H1745 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__4H__1__7N__3O__3S·HCl = 343.83 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic,Heat Sensitive |
| CAS RN | 155558-32-0 |
| PubChem Substance ID | 468592024 |
| MDL Number | MFCD06411567 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Water | max. 7.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 299 °C(dec.) |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2935.90-000 |
Application
Hydroxyfasudil Hydrochloride: An Active Metabolite of Fasudil, a Rho Kinase Inhibitor
Hydroxyfasudil hydrochloride is an active metabolite of fasudil [F0839 (HCl salt)], which is a potent and selective Rho kinase (a protein phosphatase) inhibitor. Hydroxyfasudil inhibits phosphorylation of myosin light chain, the final step in the vascular smooth muscle contractile mechanism, by inhibiting Rho kinase. Fasudil has been used as a vasodilator for the treatment of cerebral vasospasm. (The product is for research purpose only.)
References
- Pharmacological profile of hydroxyfasudil as a selective rho kinase inhibitor on ischemic brain damage
- Hydroxyfasudil, and active metabolite of fasudil hydrochloride, relaxes the rabbit basilar artery by disinhibition of myosin light chain phosphatase
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