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CAS RN: 1185167-55-8 | Product Number: I1057

2-Isopropyl-4-(N-methylaminomethyl)thiazole Dihydrochloride

Purity: >98.0%(T)(HPLC)
3   1  
10   2  

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* The storage conditions are subject to change without notice.

Product Number I1057
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__8H__1__4N__2S·2HCl = 243.19 
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Heat Sensitive
CAS RN 1185167-55-8
PubChem Substance ID 354334764
MDL Number


Appearance White to Light yellow to Light orange powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Properties (reference)
Related Laws:
Transport Information:
H.S.code* 2934.10-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
A Synthetic Intermediate of Cobicistat

This product is used for the synthesis of cobicistat which is a cytochrome P450 3A (CYP3A) inhibitor that can be used to enhance the pharmacokinetic profile of certain anti-HIV-1 agents.


  • Process for the preparation of cobicistat and intermediates thereof
    • L. R. Vadali, R. Konda, R. Dandala, WO/2015/083066
  • Process for the preparation of 1,3-thiazol-5-ylmethyl[(2R,5R)-5-{[(2S)-2- [(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl] methyl}carbamoyl)amino]-4-(morpholin-4-yl)butanoyl]amino}-1,6-diphenylhexan-2-yl]carbamate (cobicistat)
    • S. Thirumalai Rajan, S. Eswaraiah, G. Madhusudhan, K. Satyanarayana, J. Malleswara Reddy, WO/2016/132378.
  • A process for preparation of cobicistat
    • S. Simhadri, Y. Mohammad, A. R. Manda, V. S. K. Indukuri, S. R. Gorantla, C. S. Anjaneyulu, WO/2016/128885.

PubMed Literature

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