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CAS RN: 224177-60-0 | Product Number: I1090

Siramesine Hydrochloride

Purity: >98.0%(HPLC)
  • 1'-[4-[1-(4-Fluorophenyl)-1H-indol-3-yl]butyl]-3H-spiro[isobenzofuran-1,4'-piperidine] Hydrochloride
5   ≥20 
5   ≥20 

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* The storage conditions are subject to change without notice.

Product Number I1090
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__3__0H__3__1FN__2O·HCl = 491.05  
Physical State (20 deg.C) Solid
Storage Temperature <0°C
Condition to Avoid Heat Sensitive
CAS RN 224177-60-0
Reaxys Registry Number 14640899
MDL Number


Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 98.0 area%
Melting point 223.0 to 227.0 °C
Elemental analysis(Nitrogen) gt. 5.20 to 5.80 %
Properties (reference)
Melting Point 225 °C
Related Laws:
Transport Information:
H.S.code* 2934.99-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Siramesine: A σ2 Opioid Receptor Agonist

Siramesine (Lu 28-179) is a σ2 opioid receptor agonist and was first developed as an agent for the treatment of anxiety.1) It was well tolerated and non-toxic in humans but the effect was not satisfactory.2) However, after the development stopped, it has been reported that siramesine induces the death of cancer cells in vitro by destabilizing lysosomes.3-6) (The product is for research purpose only.)


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