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CAS RN: 521984-48-5 | Product Number: I1110

SIS 3 Hydrochloride

Purity: >98.0%(HPLC)
  • (E)-1-[6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl]-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one Hydrochloride
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* The storage conditions are subject to change without notice.

Product Number I1110
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__2__8H__2__7N__3O__3·HCl = 490.00 
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Store Under Inert Gas Store under inert gas
Condition to Avoid Hygroscopic,Heat Sensitive
CAS RN 521984-48-5
PubChem Substance ID 468592101
MDL Number


Appearance Light yellow to Brown powder to crystal
Purity(HPLC) min. 98.0 area%
Properties (reference)
Related Laws:
Transport Information:
H.S.code* 2933.49-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
SIS3 Hydrochloride: a specific inhibitor of Smad3

SIS3 hydrochloride is a specific inhibitor of Smad3 which has been reported as a key downstream effector of transforming growth factor-β (TGF-β) signaling in tissue fibrogenesis, and a key player in progression of fibrosis. Therefore, SIS3 has been expected as an agent for the treatment of fibrosis. (The product is for research purpose only.)


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