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CAS RN: 130018-87-0 | Product Number: L0264
Levocetirizine Dihydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 2-[2-[4-[(R)-(4-Chlorophenyl)phenylmethyl]piperazin-1-yl]ethoxy]acetic Acid Dihydrochloride
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
$45.00
|
39 | ≥40 | It can be shipped in about 2 weeks after ordering | |
| 5G |
$146.00
|
1 | 9 | It can be shipped in about 2 weeks after ordering |
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| Product Number | L0264 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__5ClN__2O__3·2HCl = 461.81 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 130018-87-0 |
| Related CAS RN
|
130018-77-8 |
| Reaxys Registry Number | 9455577 |
| PubChem Substance ID | 253661576 |
| Merck Index (14) | 2022 |
| MDL Number | MFCD07366507 |
Specifications
| Appearance | White to Almost white powder to crystaline |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 214 °C |
| Degree of solubility in water | 946 g/l |
| Solubility (insoluble in) | Acetone |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | AG0990000 |
Transport Information:
| H.S.code* | 2933.59-000 |
Application
Levocetirizine Dihydrochloride: A New Histamine H1 Antagonist with a Superior Affinity for H1 Receptors over Its Racemate, Cetirizine [C2316]
Levocetirizine dihydrochloride is a new second-generation histamine H1 antagonist, developed from cetirizine [C2316]. Chemically, levocetirizine is the active R-enantiomer of cetirizine. Levocetirizine has a superior affinity and selectivity for H1 receptors over racemic cetirizine or the S-enantiomer, and has a favorable pharmacokinetic profile.
References
- Binding characteristics of cetirizine and levocetirizine to human H1 histamine receptors: contribution of Lys191 and Thr194
- Compared pharmacological characteristics in humans of racemic cetirizine and levocetirizine, two histamine H1- receptor antagonists
- Comparison of pharmacokinetics and metabolism of desloratadine, fexofenadine, levocetirizine and mizolastine in humans (a review)
- Clinical pharmacokinetics and pharmacodynamics of desloratadine, fexofenadine and levocetirizine a comparative review
- Levocetirizine: a review of its use in the management of allergic rhinitis and skin allergies
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