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CAS RN: 145525-41-3 | Product Number: M3177

Mitiglinide Calcium

  • S,3aR,7aS)-Octahydro-γ-oxo-α-(phenylmethyl)-2H-isoindole-2-butanoic Acid Calcium Salt
19   8  
≥20  14  

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Product Number M3177
Molecular Formula / Molecular Weight C__3__8H__4__8CaN__2O__6 = 668.89  
Physical State (20 deg.C) Solid
Store Under Inert Gas Store under inert gas
Condition to Avoid Moisture Sensitive
CAS RN 145525-41-3
Reaxys Registry Number 8027952
Merck Index (14) 6211
MDL Number


Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Chelometric Titration) min. 97.0 %
Specific rotation [a]20/D +5.0 to +9.0 deg(C=1, MeOH(calcd.on anh.substance))
Water 4.5 to 6.0 %
Properties (reference)
Melting Point 185 °C
Specific Rotation 5.5° (C=1,MeOH)
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H.S.code* 2933.99-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Mitiglinide Calcium: A Fast-Acting Insulin-Releasing Agent

Mitiglinide calcium (KAD-1229; s 21403) is a glitinide class non-sulfonylurea insulinotropic agent with rapid onset. More rapidly than that of sulfonylurea antidiabetics, mitiglinide inhibits ATP-gated K+ channels and thereby causes depolarization of the B-cell membrane. The depolarization leads to activation of voltage-dependent Ca channels and Ca2+ influx into the B-cell, and eventually increases insulin release. For your reference, [O0471] is a synthetic intermediate of mitiglinide. (The product is for research purpose only.)


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