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CAS RN: 82419-36-1 | Product Number: O0403
Ofloxacin
×
Purity: >98.0%(T)(HPLC)
Synonyms:
- 9-Fluoro-3,7-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic Acid
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 5G |
$94.00
|
19 | ≥80 | Contact Us | |
| 25G |
$313.00
|
1 | 10 | Contact Us |
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| Product Number | O0403 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__8H__2__0FN__3O__4 = 361.37 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| CAS RN | 82419-36-1 |
| Reaxys Registry Number | 3657947 |
| PubChem Substance ID | 172089006 |
| Merck Index (14) | 6771 |
| MDL Number | MFCD00226105 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 263 °C |
| Maximum Absorption Wavelength | 326 nm (H__2O) |
GHS
Related Laws:
| RTECS# | UU8815500 |
Transport Information:
| H.S.code* | 2934.99-000 |
Application
Biofilm research
Susceptibility of Actinobacillus actinomycetemcomitans, strain 310a, biofilm to ofloxacin has been reported.1) The antibiotic exerted a strong inhibitory effect in both the early and mature phases of biofilm formation.
(The product is for research purpose only.)
(The product is for research purpose only.)
Reference
- Susceptibility of Actinobacillus actinomycetemcomitans to six antibiotics decreases as biofilm matures
- Ofloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use
- Quinolones in 2005: an update (a review)
- Moxifloxacin [M2479], ofloxacin, sparfloxacin [S0896], and ciprofloxacin [C2227, C2510] against Mycobacterium tuberculosis: evaluation of in vitro and pharmacodynamic indices that best predict in vivo efficacy
- Synthesis and antibacterial activities of optically active ofloxacin
- Direct determination of four fluoroquinolones, enoxacin [E0762], norfloxacin [N0817], ofloxacin, and ciprofloxacin [C2227, C2510], in pharmaceuticals and blood serum by HPLC
- Determination of ofloxacin, norfloxacin [N0817], and ciprofloxacin [C2227, C2510] in sewage by selective solid-phase extraction, liquid chromatography with fluorescence detection, and liquid chromatography-tandem mass spectrometry
- Quinolones in 2005: an update
- In vitro and in vivo activity of DL-8280, a new oxazine derivative
- Fourth generation fluoroquinolones: New weapons in the arsenal of ophthalmic antibiotics
- Direct determination of four fluoroquinolones, enoxacin, norfloxacin, ofloxacin, and ciprofloxacin, in pharmaceuticals and blood serum by HPLC
Application
Ofloxacin: A Synthetic Fluoroquinolone Antimicrobial, Ofloxacin
Ofloxacin is a synthetic fluoroquinolone antimicrobial structurally related to nalidixic acid [N0490]. Ofloxacin has broad-spectrum bactericidal activity against most Gram-negative bacteria, many Gram-positive bacteria and some anaerobes. The mechanism of action of ofloxacin (and other fluoroquinolone) involves inhibition of bacterial topoisomerase IV and DNA gyrase (topoisomerases II), enzymes required for DNA replication, transcription, repair and recombination. The active S-(-)-enantiomer of ofloxacin is levofloxacin [L0193]. (The product is for research purpose only.)
References
Application
Studies of the Antimicrobial Activity and the Determination of Ofloxacin
References
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