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CAS RN: 144689-24-7 | Product Number: O0507


Purity: >98.0%(HPLC)
3   ≥20 

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* The storage conditions are subject to change without notice.

Product Number O0507
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__2__4H__2__6N__6O__3 = 446.51  
Physical State (20 deg.C) Solid
Storage Temperature <0°C
Condition to Avoid Heat Sensitive
CAS RN 144689-24-7
Reaxys Registry Number 7502669
PubChem Substance ID 354335584
MDL Number


Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 95.0 %
Properties (reference)
Melting Point 177 °C(dec.)
Related Laws:
RTECS# NI4014100
Transport Information:
H.S.code* 2933.99-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Olmesartan: A Selective AT1 Subtype Angiotensin II Receptor Antagonist (“sartan”)

Olmesartan, an active metabolite of olmesartan medoxomil [O0510], is a selective AT1 subtype angiotensin II receptor antagonist (“sartan”), such as candesartan [C2635], eprosartan [E1161], irbesartan [I0859], losartan [L0232], olmesartan [O0507], telmisartan [T2861] and valsartan [V0112].
Angiotensin II is formed from angiotensin I in a reaction catalyzed by angio-tensin converting angiotensin conversion enzyme (ACE), and can active two different receptors, AT1 and AT2, both of which are coupled to G-protein. The vasopressor actions of angiotensin II are mediated through AT1 receptors. Olmesartan and sartans bind selectively to AT1 receptor with almost no binding to AT2 receptor in vascular smooth muscle. Therefore, olmesartan and sartans show blood pressure lowering effect. Recently, some combination agents with a calcium channel antagonist (e.g. amlodipine [A2353], azelnidipine [A2433]) are also used for the treatment of hypertension and cardiovascular disease. (The product is for research purpose only.)


PubMed Literature

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