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CAS RN: 130-95-0 | Product Number: Q0028

Quinine


Purity: >98.0%(T)
Synonyms:
Documents:
25G
$124.00
≥20  ≥20 
100G
$342.00
15   ≥20 

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Product Number Q0028
Purity / Analysis Method >98.0%(T)
Molecular Formula / Molecular Weight C__2__0H__2__4N__2O__2 = 324.42  
Physical State (20 deg.C) Solid
Store Under Inert Gas Store under inert gas
Condition to Avoid Light Sensitive,Hygroscopic
CAS RN 130-95-0
Reaxys Registry Number 5293630
PubChem Substance ID 87575561
SDBS (AIST Spectral DB) 2170
Merck Index (14) 8061
MDL Number

MFCD00198096

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 96.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Melting point 174.0 to 179.0 °C
Specific rotation [a]20/D -160 to -170 deg(C=2, EtOH)
Solubility in Methanol almost transparency
Properties (reference)
Melting Point 177 °C
Specific Rotation -165° (C=2,EtOH)
Solubility in water Insoluble
Solubility (very soluble in) Methanol,Ethanol
Solubility (very slightly) Ether
GHS
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H302 : Harmful if swallowed.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
H317 : May cause an allergic skin reaction.
H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray.
P272 : Contaminated work clothing should not be allowed out of the workplace.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P284 : Wear respiratory protection.
P302 + P352 : IF ON SKIN: Wash with plenty of water.
P342 + P311 : If experiencing respiratory symptoms: Call a POISON CENTER/doctor.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P304 + P340 : IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
Related Laws:
RTECS# VA6020000
Transport Information:
H.S.code* 2939.20-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Application
Quinine, an Antimalarial Substance

  Quinine is one of the alkaloids which is included in the bark of cinchona tree and has been researched since 19th century.1) It has an anti-malarial activity2-4) and is considered to inhibit heme polymerase of plasmodium and to indicate toxicity to plasmodium. There are other antimalarial substances such as chloroquine diphosphate [C2301], hydroxychloroquine sulfate [H1306] and artemisinin [A2118]. (The product is for research purpose only)

References


Application
Asymmetric Tandem Michael Addition/Oxidation of Pyrazolones with p-Benzoquinone Using Cinchona Alkaloid Catalysts

B0089,Q0028

Typical Procedure:
p-Benzoquinone (42.6 mg, 0.4 mmol) and quinine (1.3 mg, 2 mol%) are dissolved in 1,2-dichloroethane (2 mL). The solution is stirred at 25 °C for 10 min, after which a 4-substituted pyrazol-5-one (0.2 mmol) is added to the mixture. The solution is stirred at 25 °C for 24 h. Next, the solvent is removed under reduced pressure. The residue is directly subjected to column chromatography (petroleum ether/EtOAc = 10:1–6:1) to afford the desired product.

References


PubMed Literature


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