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CAS RN: 90098-04-7 | Product Number: R0085

Rebamipide


Purity: >98.0%(HPLC)
Synonyms:
  • 2-(4-Chlorobenzamido)-3-[2(1H)-quinolinon-4-yl]propionic Acid
Documents:
1G
$75.00
16   ≥20 
5G
$192.00
≥20  ≥20 
25G
$595.00
15   ≥20 

* Please contact our distributors or TCI to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.


Product Number R0085
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__1__9H__1__5ClN__2O__4 = 370.79  
Physical State (20 deg.C) Solid
CAS RN 90098-04-7
Reaxys Registry Number 5384689
PubChem Substance ID 125307349
Merck Index (14) 8124
MDL Number

MFCD11114396

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 95.0 %
Properties (reference)
Melting Point 290 °C(dec.)
GHS
Related Laws:
RTECS# VC2518500
Transport Information:
H.S.code* 2933.49-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Application
Rebamipide: A Quinolinone Analog for Gastric Mucosal Protection

Rebamipide (OPC-12759), a 2(1H)-quinolinone analog, is used as an anti-gastritis and anti-gastric ulcer agent. It has been reported to have various activities in the gastric mucosa, such as stimulation of prostaglandin and mucus glycoprotein synthesis, inhibition of reactive oxygen species, inflammatory cytokines and chemokines, and inhibition of neutrophils activation. Furthermore, inhibition of gastric tumor growth by rebamipide has also been reported. In addition, rebamipide is used as a therapeutic adjunct for the treatment of infections caused by Helicobacter pylori. For your reference, we also have a related synthetic intermediate [O0468] of rebamipide. (The product is for research purpose only.)

References


Application
Induction of Cyclooxygenase-2 (COX-2) in Rat Gastric Mucosa by Rebamipide

Reference

  • Induction of Cyclooxygenase-2 in Rat Gastric Mucosa by Rebamipide, a Mucoprotective Agent
    • M. Yasumaru, H. Iijima, Y. Okuda, Y. Sasaki, M. Hori, S. Kawano, J. Pharmacol. Exp. Ther. 2000, 295, 447.


PubMed Literature


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