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CAS RN: 76-66-4 | Product Number: R0105
Rhynchophylline
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Purity: >98.0%(HPLC)
Synonyms:
Product Documents:
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| Product Number | R0105 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__2__8N__2O__4 = 384.48 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 76-66-4 |
| PubChem Substance ID | 253660200 |
| Merck Index (14) | 8197 |
| MDL Number | MFCD00221748 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 200.0 to 208.0 °C |
| Specific rotation [a]20/D | -21.0 to -25.0 deg(C=1, CHCl3) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 206 °C |
| Specific Rotation | -23° (C=1,CHCl3) |
| Maximum Absorption Wavelength | 247 nm |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Chloroform |
| Solubility (slightly sol. in) | Ethanol, Acetone |
GHS
Related Laws:
| RTECS# | GN1600000 |
Transport Information:
| H.S.code* | 2939.79-000 |
Application
Rhynchophylline: an Antihypertensive and Neuroprotective Alkaloid
Rhynchophylline is major tetracyclic oxindole alkaloid components of Uncaria species. Rhynchophylline has drawn extensive attention in recent years for its antihypertensive and neuroprotective activities. The active mechanisms would be related to blocking of calcium channel, opening of potassium channel, and regulating of nerve transmitters transport and metabolism, etc.
References
- Rhynchophylline and isorhynchophylline inhibit NMDA receptors expressed in Xenopus oocytes
- Protective effect of rhynchophylline and isorhynchophylline on in vitro ischemia-induced neuronal damage in the hippocampus: putative neurotransmitter receptors involved in their action
- Rhynchophylline from Uncaria rhynchophylla Functionally Turns Delayed Rectifiers into A-Type K+ Channels
- Pharmacological actions of uncaria alkaloids, rhynchophylline and isorhynchophylline
- Antihypertensive and neuroprotective activities of rhynchophylline: The role of rhynchophylline in neurotransmission and ion channel activity
PubMed Literature
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