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CAS RN: 135062-02-1 | Product Number: R0179

Repaglinide


Purity: >98.0%(T)(HPLC)
Synonyms:
  • (S)-(+)-2-Ethoxy-4-[N-[1-(2-piperidinophenyl)-3-methyl-1-butyl]aminocarbonylmethyl]benzoic Acid
Documents:
200MG
$81.00
≥20  Contact Us
1G
$281.00
8   ≥20 

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* The storage conditions are subject to change without notice.


Product Number R0179
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__2__7H__3__6N__2O__4 = 452.60  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Heat Sensitive
CAS RN 135062-02-1
Reaxys Registry Number 8238956
PubChem Substance ID 253661221
Merck Index (14) 8136
MDL Number

MFCD00906179

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %
Melting point 131.0 to 135.0 °C
Specific rotation [a]20/D +7.0 to +10.0 deg(C=1,MeOH)
Properties (reference)
Melting Point 133 °C
Specific Rotation 9° (C=1,MeOH)
GHS
Pictogram Pictogram Pictogram
Signal Word Warning
Hazard Statements H302 : Harmful if swallowed.
H361 : Suspected of damaging fertility or the unborn child.
H362 : May cause harm to breast-fed children.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P263 : Avoid contact during pregnancy/ while nursing.
P260 : Do not breathe dusts or mists.
P270 : Do not eat, drink or smoke when using this product.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
P405 : Store locked up.
Related Laws:
RTECS# DI0876305
Transport Information:
H.S.code* 2933.39-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Application
Repaglinide: A Fast-Acting Insulin-Releasing Agent

Repaglinide, a carbamoylmethyl benzoic acid derivative, is a fast-acting insulin-releasing agent. Its mechanism of action is partly similar to that of the sulfonylureas such as glibenclamide [G0382] which binds to the sulfonylurea binding sites on pancreatic β-cells resulting in reducing blood glucose. For details, repaglinide stimulates the release of insulin from pancreatic β-cells by closing ATP-sensitive potassium channels, which results in the opening of calcium channels in the β-cells. Repaglinide is metabolized by CYP2C8 and CYP3A4 enzymes. Repaglinide is used for the treatment of type 2 diabetes. For your reference, [E0928] is a synthetic intermediate of repaglinide. (The product is for research purpose only.)

References


PubMed Literature


Documents (Note: Some products will not have analytical charts available.)
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