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CAS RN: 112887-68-0 | Product Number: R0208


Purity: >98.0%(HPLC)
  • N-[[5-[[(1,4-Dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2-thienyl]carbonyl]-L-glutamic Acid
  • ZD-1694
  • ICI-D-1694
13   ≥20 
≥20  4  

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* The storage conditions are subject to change without notice.

Product Number R0208
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__2__1H__2__2N__4O__6S = 458.49  
Physical State (20 deg.C) Solid
Storage Temperature <0°C
Condition to Avoid Heat Sensitive
CAS RN 112887-68-0
Reaxys Registry Number 4359638
Merck Index (14) 8099
MDL Number


Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 97.0 %
Specific rotation [a]20/D -15.0 to -20.0 deg(C=1,MeOH)
Properties (reference)
Melting Point 176 °C(dec.)
Specific Rotation -17° (C=1,MeOH)
Solubility in water Soluble
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 : Toxic if swallowed.
H360 : May damage fertility or the unborn child.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P405 : Store locked up.
Related Laws:
RTECS# MA1253250
Transport Information:
UN Number UN2811
Class 6.1
Packing Group III
H.S.code* 2934.99-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Raltitrexed: A Thymidylate Synthase (TS) Inhibitor

Raltitrexed (or ZD1694) is a quinazoline-based folate analogue that selectively inhibits thymidylate synthase (TS). TS is a folate [F0043]-dependent enzyme that catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) [D3673] to 2'-deoxythymidine-5'-monophosphate (dTMP) [T0845, Na salt]. This pathway is crucial for DNA synthesis, because TS is a key enzyme in the synthesis of thymidine-5’-triphosphate (dTTP) which is required exclusively for DNA synthesis. The inhibition of TS leads to DNA fragmentation and cell death. Therefore, TS represents a critical target in cancer chemotherapy. In clinical studies, raltitrexed is also used in combination with other antitumor agents. (The product is for research purpose only.)


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