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CAS RN: 5086-74-8 | Product Number: T3663
Tetramisole Hydrochloride
×
Purity: >98.0%(HPLC)(N)
Synonyms:
- 6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole Hydrochloride
Product Documents:
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| 10G |
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| Product Number | T3663 |
Purity / Analysis Method 
|
>98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__1H__1__2N__2S·HCl = 240.75 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 5086-74-8 |
| Related CAS RN
|
5036-02-2 |
| Reaxys Registry Number | 4358987 |
| PubChem Substance ID | 354335797 |
| Merck Index (14) | 5459 |
| MDL Number | MFCD00005536 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 260 °C |
| Solubility in water | Soluble |
| Degree of solubility in water | 210 g/l 20 °C |
| Solubility (soluble in) | Methanol |
| Solubility (slightly sol. in) | Acetone, Chloroform |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | NJ5950000 |
Transport Information:
| H.S.code* | 2934.99-000 |
Application
Tetramisole Hydrochloride: An Alkaline Phosphatase Inhibitor and an Anthelminthic Agent
Tetramisole hydrochloride is an alkaline phosphatase inhibitor.1-3) It is a racemic mixture of (+) and (-) isomers. The (-) isomer, levamisole hydrochloride [L0231] [T1215], is the active enantiomer.4) Tetramisole and levamisole are also used as an anthelminthic agent for the treatment of helminth or worm infections.5,6) Reportedly, they work as a nicotinic acetylcholine receptor agonist that causes continued stimulation of the parasitic worm muscles, leading to paralysis.7) (The product is for research purpose only.)
References
- 1)Alkaline phosphatase is an ectoenzyme that acts on micromolar concentrations of natural substrates at physiologic pH in human osteosarcoma (SAOS-2) cells
- 2)Evidence of the Presence of a Specific ATPase Responsible for ATP-initiated Calcification by Matrix Vesicles Isolated from Cartilage and Bone
- 3)Further characterization of ATP-initiated calcification by matrix vesicles isolated from rachitic rat cartilage: Membrane perturbation by detergents and deposition of calcium pyrophosphate by rachitic matrix vesicles
- 4)Stereospecific inhibition of alkaline phosphatase by L-tetramisole prevents in vitro cartilage calcification
- 5)Tetramisole (R 8299), a new, potent broad spectrum anthelmintic
- 6)Novel broad-spectrum anthelmintics. Tetramisole and related derivatives of 6-arylimidazo[2,1-b]thiazole
- 7)Levamisole receptors: a second awakening (a review)
- 8)Determination of levamisole and tetramisole in seized cocaine samples by enantioselective high-performance liquid chromatography and circular dichroism detection
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