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CAS RN: 74711-43-6 | Product Number: Z0021


Purity: >98.0%(T)(HPLC)
  • 2-(10,11-Dihydro-10-oxodibenzo[b,f]thiepin-2-yl)propionic Acid
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* The storage conditions are subject to change without notice.

Product Number Z0021
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__7H__1__4O__3S = 298.36 
Physical State (20 deg.C) Solid
Condition to Avoid Light Sensitive
CAS RN 74711-43-6
Reaxys Registry Number 6770548
PubChem Substance ID 160871191
Merck Index (14) 10112
MDL Number


Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %
Melting point 135.0 to 139.0 °C
Properties (reference)
Melting Point 137 °C
Solubility in water Insoluble
Solubility (very soluble in) Chloroform,Acetone
Solubility (soluble in) Methanol
Solubility (slightly sol. in) Benzene,Ethanol
Pictogram Pictogram
Signal Word Warning
Hazard Statements H302 : Harmful if swallowed.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
Related Laws:
RTECS# HQ2526700
Transport Information:
H.S.code* 2934.99-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Studies on Nonsteroidal Anti-Inflammatory Drugs (NSAID)

Comparison of cyclooxygenase-1 and -2 inhibitory activities of various nonsteroidal anti-inflammatory drugs using human platelets and synovial cells

S. Kawai, S. Nishida, M. Kato, Y. Furumaya, R. Okamoto, T. Koshino, Y. Mizushima, Eur. J. Pharmacol. 1998, 347, 87.

Zaltoprofen inhibits bradykinin-induced responses by blocking the activation of second messenger signaling cascades in rat dorsal root ganglion cells

H. Tang, A. Inoue, K. Oshita, K. Hirate, Y. Nakata, Neuropharmacology 2005, 48, 1035.

Pharmacological investigations of the new antiinflammatory agent 2-(10,11-dihydro-10-oxodibenzo[b,f]thiepin-2-yl)propionic acid. 1st Communication: Inhibitory effects on rat paw edema

K. Tsurumi, K. Kyuki, M. Niwa, S. Kokuba, H. Fujimura, Arzneim.-Forsch. 1986, 36, 1796.

Analgesic and antiinflammatory effects of 2-(10,11-dihydro-10-oxo-dibenzo[b,f]thiepin-2-yl)propionic acid in rat and mouse

T. Kameyama, T. Nabeshima, S. Yamada, M. Sato, Arzneim.-Forsch. 1987, 37, 19.

PubMed Literature

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