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Published TCIMAIL newest issue No.198
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CAS RN: 52-86-8 | Product Number: H0912
Haloperidol
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 4-[4-(4-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 5G |
€71.00
|
Contact Us | 18 |
| 25G |
€244.00
|
2 | ≥40 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | H0912 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__3ClFNO__2 = 375.87 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 52-86-8 |
| Reaxys Registry Number | 331267 |
| PubChem Substance ID | 87571270 |
| SDBS (AIST Spectral DB) | 14024 |
| Merck Index (14) | 4598 |
| MDL Number | MFCD00051423 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Solubility in Acetic acid | almost transparency |
| Melting point | 150.0 to 153.0 °C |
Properties (reference)
| Melting Point | 152 °C |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Chloroform, Acetone, Benzene |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H360 : May damage fertility or the unborn child. H362 : May cause harm to breast-fed children. H370 : Causes damage to organs. H372 : Causes damage to organs through prolonged or repeated exposure. |
| Precautionary Statements | P263 : Avoid contact during pregnancy and while nursing. P260 : Do not breathe dust. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. |
Related Laws:
| EC Number | 200-155-6 |
| RTECS# | EU1575000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2933399990 |
Application
Efflux Pump research
References
- Synergistic Effects of Efflux Pump Modulators on the Azole Antifungal Susceptibility of Microsporum canis
- Repurposing pantoprazole and haloperidol as efflux pump inhibitors in azole resistant clinical Candida albicans and non-albicans isolates
Application
Haloperidol: A Dopamine Receptor (D2) and a Serotonin Receptor (5-HT2) Antagonist
Haloperidol is a butyrophenone series of neurotransmitter agent. The precise mechanism of action has not been clearly established, but it has been shown to be a dopamine receptor (D2) and a serotonin receptor (5-HT2) antagonist. Therefore, haloperidol is classified as a neuroleptic. Haloperidol is metabolized by several routes including the cytochrome P450 enzyme system (particularly CYP3A4 or CYP2D6). Hence, haloperidol inhibits the metabolism of tricyclic antidepressants such as doxepin hydrochloride [D4626] and imipramine hydrochloride [I0971] , increasing the blood levels of these agents. Haloperidol has no anti-histaminergic or anticholinergic activity. Haloperidol is almost insoluble in water, but is soluble in most organic solvents. (The product is for research purpose only.)
References
- Serotonergic involvement in haloperidol-induced catalepsy
- A common action of clozapine, haloperidol, and remoxipride on D1- and D2-dopaminergic receptors in the primate cerebral cortex
- Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist
- Pharmacokinetics of haloperidol: an update (a review)
- Antipsychotic drugs and neuroplasticity: insights into the treatment and neurobiology of schizophrenia (a review)
PubMed Literature
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