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CAS RN: 154229-18-2 | Product Number: A2891
Abiraterone Acetate
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 3β-17-(3-Pyridyl)androsta-5,16-dien-3-ol Acetate
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 200MG |
NT$6,384
|
≥100 | 7 | Contact Us | |
| 1G |
NT$19,068
|
≥60 | 0 | Contact Us |
* The above prices include freight cost, customs, and other charges to the destination except for products that need to be shipped by sea or dry ice. For details, please contact
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* The storage conditions are subject to change without notice.
| Product Number | A2891 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__6H__3__3NO__2 = 391.56 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image), 200MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 154229-18-2 |
| Reaxys Registry Number | 7314563 |
| PubChem Substance ID | 253661226 |
| MDL Number | MFCD00934213 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 145.0 to 149.0 °C |
| Specific rotation [a]20/D | -40.0 to -45.0 deg(C=2,EtOH) |
Properties (reference)
| Melting Point | 147 °C |
| Specific Rotation | -43° (C=2,EtOH) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H361 : Suspected of damaging fertility or the unborn child. H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | BV7992100 |
Transport Information:
| H.S.code* | 2937.29-000 |
Application
Abiraterone Acetate: A Prodrug of Abiraterone [A2868]
Abiraterone acetate (CB7630) is a prodrug of abiraterone [A2868] which is a selective inhibitor of the steroidogenic enzyme cytochrome P450 17A1 (CYP17A1) which catalyzes two key serial reactions (17α-hydroxylase hydroxylase and 17,20-lyase) in androgen and estrogen biosynthesis. Abiraterone is more potent than ketoconazole [K0045] as an inhibitor of CYP17. Abiraterone acetate is an agent used in combination with prednisone [P1276] in metastatic castration-resistant prostate cancer (mCRPC). (The product is for research purpose only.)
References
- Pharmacology of novel steroidal inhibitors of cytochrome P45017α (17α-hydroxylase/C17–20 lyase)
- Effects of novel 17α-hydroxylase/C17, 20-lyase (P450 17, CYP 17) inhibitors on androgen biosynthesis in vitro and in vivo
- CYP17 inhibition as a hormonal strategy for prostate cancer
- Abiraterone acetate: in metastatic castration-resistant prostate cancer (a review)
- Abiraterone Acetate: A Review of Its Use in Patients with Metastatic Castration-Resistant Prostate Cancer
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