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CAS RN: 198904-31-3 | Product Number: A3469
Atazanavir
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Purity: >95.0%(HPLC)
Synonyms:
- Methyl [(5S,10S,11S,14S)-11-Benzyl-5-tert-butyl-10-hydroxy-15,15-dimethyl-3,6,13-trioxo-8-[4-(2-pyridinyl)benzyl]-2-oxa-4,7,8,12-tetraazahexadecan-14-yl]carbamate
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 5G |
NT$6,972
|
0 | 12 | Contact Us |
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* The storage conditions are subject to change without notice.
| Product Number | A3469 |
Purity / Analysis Method 
|
>95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__3__8H__5__2N__6O__7 = 704.87 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 198904-31-3 |
| Reaxys Registry Number | 8101951 |
| MDL Number | MFCD08435966 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Melting point | 200.0 to 204.0 °C |
| Specific rotation | -43.0 to -47.0 deg (C=1, ethanol) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 203 °C |
GHS
Related Laws:
| RTECS# | RY8694000 |
Transport Information:
| H.S.code* | 2933.39-000 |
Application
Atazanavir: An Azapeptide Protease Inhibitor
Atazanavir (BMS-232632) is a human immunode ficiency virus type 1 (HIV-1) protease inhibitor that prevents the formation of mature virions in HIV-1-infected cells by inhibiting the cleavage of gag and gag-pol polyproteins.1,2) Atazanavir is often used with ritonavir [R0116], a pharmacokinetic enhancer (booster), since it is metabolized by cytochrome P450 isoenzyme 3A4 to inactive metabolites.2) It has recently been reported that atazanavir inhibits SARS-CoV-2 replication and proinflammatory cytokine production.3) (The product is for research purpose only.)
References
- 1) BMS-232632, a highly potent human immunodeficiency virus protease inhibitor that can be used in combination with other available antiretroviral agents
- 2) Atazanavir: A review of its use in the management of HIV-1 infection (a review)
- 3) Atazanavir, alone or in combination with ritonavir, inhibits SARS-CoV-2 replication and proinflammatory cytokine production
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