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CAS RN: 125316-60-1 | Product Number: A3612
CD 437

Purity: >93.0%(qNMR)
Synonyms:
- AHPN
- 6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic Acid
- 6-[4-Hydroxy-3-[tricyclo[3.3.1.13,7]decan-1-yl]phenyl]-2-naphthoic Acid
Product Documents:
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Product Number | A3612 |
Purity / Analysis Method | >93.0%(qNMR) |
Molecular Formula / Molecular Weight | C__2__7H__2__6O__3 = 398.50 |
Physical State (20 deg.C) | Solid |
Storage Temperature | Frozen (-20°C) |
Condition to Avoid | Heat Sensitive |
CAS RN | 125316-60-1 |
Reaxys Registry Number | 7445028 |
MDL Number | MFCD03106506 |
Specifications
Appearance | White to Light gray to Light yellow powder to crystal |
Purity(HPLC) | min. 95.0 area% |
Purity(qNMR) | min. 93.0 % |
NMR | confirm to structure |
Properties (reference)
Melting Point | 275 °C |
GHS
Related Laws:
RTECS# | QJ1975900 |
Transport Information:
H.S.code* | 2918.29-000 |
Application
CD 437: A Selective Retinoic Acid Receptor (RARγ) Agonist
CD 437 (AHPN) is a synthetic retinoid-like small molecule that is a selective retinoic acid receptor (RARγ) agonist. There are reports that CD 437 selectively induces apoptosis in cancer cells.1-4) In addition, CD 437 has been reported to show significant efficacy in a mouse model of chronic MRSA infection.5) (The product is for research purpose only.)
References
- 1) p53 Independent G0/G1 arrest and apoptosis induced by a novel retinoid in human breast cancer cells
- 2) Classical and novel retinoids: Their targets in cancer therapy (a review)
- 3) Targeting Nur77 translocation (a review)
- 4) The antitumor toxin CD437 is a direct inhibitor of DNA polymerase α
- 5) A new class of synthetic retinoid antibiotics effective against bacterial persisters
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