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CAS RN: 54863-37-5 | Product Number: D5955
Dapansutrile
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Purity: >98.0%(GC)
Synonyms:
- OLT 1177
- 3-(Methylsulfonyl)propanenitrile
- 3-(Methylsulfonyl)propionitrile
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 100MG |
NT$6,510
|
4 | 0 | It can be shipped in about 2 weeks after ordering | |
| 1G |
NT$34,566
|
14 | 0 | It can be shipped in about 2 weeks after ordering |
* The above prices include freight cost, customs, and other charges to the destination except for products that need to be shipped by sea or dry ice. For details, please contact
our distributor
in Taiwan to order our product.
* The storage conditions are subject to change without notice.
| Product Number | D5955 |
Purity / Analysis Method 
|
>98.0%(GC) |
| Molecular Formula / Molecular Weight | C__4H__7NO__2S = 133.17 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container
|
100MG-Glass Bottle with Plastic Insert (View image), 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 54863-37-5 |
| Reaxys Registry Number | 1751247 |
| PubChem Substance ID | 468591664 |
| MDL Number | MFCD11934305 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 73.0 to 77.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 75 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. |
Related Laws:
Transport Information:
| H.S.code* | 2930.90-900 |
Application
Dapansutrile (OLT1177): An Orally Active NLRP3 inflammasome Inhibitor
Recently, it has been reported that the NLR family pyrin domain-containing protein 3 (NLRP3), a pattern recognition receptor, forms a complex called the NLRP3 inflammasome in response to irritant metabolites and pathogens and induces the production of pro-inflammatory cytokines, interleukin (IL)-1β and IL-18. The NLRP3 inflammasome has been implicated in a wide range of diseases, including Alzheimer’s disease, Prion diseases, type 2 diabetes, and some infectious diseases. Dapansutrile (OLT1177), a β-sulfonyl nitrile compound, is an orally active NLRP3 inflammasome inhibitor with anti-inflammatory activity. (The product is for research purpose only.)
References
- OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation
- NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis
- The NLRP3 Inflammasome Inhibitor, OLT1177 (Dapansutrile), Reduces Infarct Size and Preserves Contractile Function After Ischemia Reperfusion Injury in the Mouse
- The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer's disease
- Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors (a review)
Documents
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Specifications
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