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CAS RN: 164656-23-9 | Product Number: D5973
Dutasteride

Purity: >98.0%(HPLC)
Synonyms:
- (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-[2,5-Bis(trifluoromethyl)phenyl]-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide
- (5α,17β)-N-[2,5-Bis(trifluoromethyl)phenyl]-3-oxo-4-azaandrost-1-ene-17-carboxamide
Product Documents:
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500MG |
NT$11,400
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≥60 | 1 | Contact Us |
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Product Number | D5973 |
Purity / Analysis Method | >98.0%(HPLC) |
Molecular Formula / Molecular Weight | C__2__7H__3__0F__6N__2O__2 = 528.54 |
Physical State (20 deg.C) | Solid |
Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
Store Under Inert Gas | Store under inert gas |
Condition to Avoid | Air Sensitive |
Packaging and Container | 500MG-Glass Bottle with Plastic Insert (View image) |
CAS RN | 164656-23-9 |
Reaxys Registry Number | 7401530 |
PubChem Substance ID | 468591669 |
MDL Number | MFCD00937869 |
Specifications
Appearance | White to Light yellow powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Melting point | 246.0 to 250.0 °C |
Specific rotation | +20.0 ~ +24.0 deg(C=1, CHCl3) |
NMR | confirm to structure |
Properties (reference)
Melting Point | 248 °C |
Solubility in water | Insoluble |
Solubility (soluble in) | Acetone, Ethanol, Chloroform, Methanol |
GHS
Related Laws:
RTECS# | NK9466600 |
Transport Information:
H.S.code* | 2937.29-000 |
Application
Dutasteride: A Selective Inhibitor of both the Type 1 and Type 2 Isoforms of 5α-Reductase
Dutasteride (GG745), a synthetic 4-azasteroid compound, is a selective inhibitor of both the type 1 and type 2 isoforms of steroid 5α-reductase, and blocks the conversion of testosterone [T0027] to 5α-dihydrotestosterone (DHT) [A0462] in target organs such as the prostate and scalp hair.1-4) It has been reported that dutasteride is a more potent inhibitor of type 1 (45-fold) and type 2 5α (2.5-fold) than finasteride [F0675] (a type 2 5α inhibitor) in vitro.4) Dutasteride also has been studied for its ability to reduce the incidence of prostate cancer.4) (The product is for research purpose only.)
References
- 1) Mechanism of Time-Dependent Inhibition of 5.alpha.-Reductases by .DELTA.1-4-Azasteroids: Toward Perfection of Rates of Time-Dependent Inhibition by Using Ligand-Binding Energies
- 2) Unique Preclinical Characteristics of GG745, A Potent Dual Inhibitor of 5AR
- 3) An overview on 5α-reductase inhibitors (a review)
- 4) Dutasteride: a review of its use in the management of prostate disorders (a review)
- 5) RP-HPLC method for the estimation of dutasteride in tablet dosage form
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