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CAS RN: 19235-17-7 | Product Number: H1863
5-(Hydroxymethyl)cytidine
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Purity: >95.0%(HPLC)
Synonyms:
- 5-Hydroxymethylcytidine
- 4-Amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-(hydroxymethyl)pyrimidin-2(1H)-one
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 50MG |
NT$9,954
|
15 | 0 | Contact Us | |
| 200MG |
NT$24,822
|
33 | 0 | Contact Us |
* The above prices include freight cost, customs, and other charges to the destination except for products that need to be shipped by sea or dry ice. For details, please contact
our distributor
in Taiwan to order our product.
* The storage conditions are subject to change without notice.
| Product Number | H1863 |
Purity / Analysis Method 
|
>95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__0H__1__5N__3O__6 = 273.25 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container
|
200MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 19235-17-7 |
| Reaxys Registry Number | 553746 |
| MDL Number | MFCD26523159 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Melting point | 214.0 to 218.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 216 °C |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2934.99-000 |
Application
5-(Hydroxymethyl)cytidine: An Important Base-modified Ribonucleoside in Epigenetics
5-(Hydroxymethyl)cytidine (hm5C) is a modified ribonucleoside that has long been known to be present in mRNA, tRNA, and rRNA. 5-(Hydroxymethyl)cytidine in RNA is generated by 5-methylcytidine (m5C) [M1931] oxidation in vivo. Recent studies have discovered that 5-(hydroxymethyl)cytidine is a prevalent mRNA modification in eukaryotes and has roles in cell viability and development through these effects on RNA as follows; RNA structure and translation efficiency.1,2) In addition, 5-(hydroxymethyl)cytidine has been reported to have important functions in the nervous system.3-5)
References
- 1) Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells
- 2) Formation and Abundance of 5-Hydroxymethylcytosine in RNA
- 3) Transcriptome-wide distribution and function of RNA hydroxymethylcytosine
- 4) Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients
- 5) Quantification of the Sixth DNA Base Hydroxymethylcytosine in the Brain
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