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CAS RN: 1185167-55-8 | Product Number: I1057
2-Isopropyl-4-(N-methylaminomethyl)thiazole Dihydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
NT$966
|
1 | 1 | It can be shipped in about 2 weeks after ordering | |
| 5G |
NT$3,360
|
1 | 0 | It can be shipped in about 2 weeks after ordering |
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| Product Number | I1057 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__8H__1__4N__2S·2HCl = 243.19 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 1185167-55-8 |
| PubChem Substance ID | 354334764 |
| MDL Number | MFCD11841218 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
GHS
Related Laws:
Transport Information:
| H.S.code* | 2934.10-000 |
Application
A Synthetic Intermediate of Cobicistat
This product is used for the synthesis of cobicistat which is a cytochrome P450 3A (CYP3A) inhibitor that can be used to enhance the pharmacokinetic profile of certain anti-HIV-1 agents.
References
- Process for the preparation of cobicistat and intermediates thereof
- L. R. Vadali, R. Konda, R. Dandala, WO/2015/083066
- Process for the preparation of 1,3-thiazol-5-ylmethyl[(2R,5R)-5-{[(2S)-2- [(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl] methyl}carbamoyl)amino]-4-(morpholin-4-yl)butanoyl]amino}-1,6-diphenylhexan-2-yl]carbamate (cobicistat)
- S. Thirumalai Rajan, S. Eswaraiah, G. Madhusudhan, K. Satyanarayana, J. Malleswara Reddy, WO/2016/132378.
- A process for preparation of cobicistat
- S. Simhadri, Y. Mohammad, A. R. Manda, V. S. K. Indukuri, S. R. Gorantla, C. S. Anjaneyulu, WO/2016/128885.
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