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CAS RN: 97792-45-5 | Product Number: L0272
Lappaconitine Hydrobromide
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Purity: >95.0%(N)
Synonyms:
Product Documents:
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| 200MG |
NT$4,578
|
0 | 10 | Contact Us |
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| Product Number | L0272 |
Purity / Analysis Method 
|
>95.0%(N) |
| Molecular Formula / Molecular Weight | C__3__2H__4__4N__2O__8·HBr = 665.62 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 97792-45-5 |
| Related CAS RN
|
32854-75-4 |
| Reaxys Registry Number | 3868594 |
| PubChem Substance ID | 253662089 |
| MDL Number | MFCD00171334 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 93.0 area% |
| Purity(with Total Nitrogen) | min. 95.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 222 °C(dec.) |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 : Fatal if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | AR5569600 |
Transport Information:
| UN Number | UN1544 |
| Class | 6.1 |
| Packing Group | II |
| H.S.code* | 2939.79-000 |
Application
Lappaconitine hydrobromide: A Diterpene Alkaloid Working as an Inhibitor of Voltage-Dependent Sodium Channels
Lappaconitine hydrobromide is a diterpene alkaloid extracted from roots of Aconitum sinomantanum. It is a non-narcotic central nervous system analgesic. Lappaconitine also has antiarrhythmic and anti-inflammatory effect. Lappaconitine works as an inhibitor of tetrodotoxin-sensitive, voltage-dependent sodium channels. On the other hand, lappaconitine is reported as an organocatalyst for asymmetric α-hydroxylation of β-keto esters. (The product is for research purpose only.)
References
- Pharmacological studies on lappaconitine: antinociception and inhibition of the spinal action of substance P and somatostatin
- Cardiac effects of lappaconitine and N-deacetyllappaconitine. Two diterpenoid alkaloids from plants of the Aconitum and Delphinium species
- Mode of antinociceptive and toxic action of alkaloids of Aconitum spec
- Diterpenoid alkaloids as a new class of antiarrhythmic agents. Structure-activity relationship
- Irreversible block of human heart (hH1) sodium channels by the plant alkaloid lappaconitine
- Pharmacokinetic study of lappaconitine hydrobromide in mice by LC-MS
- Lappaconitine-catalyzed asymmetric α-hydroxylation of β-keto esters: a Brønsted base organocatalyst developed from terpenoid alkaloids
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