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CAS RN: 73232-52-7 | Product Number: M3504
Methylnaltrexone Bromide
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Purity: >95.0%(HPLC)(qNMR)
Synonyms:
- 17-(Cyclopropylmethyl)-3,14-dihydroxy-17-methyl-6-oxo-5α-4,5-epoxymorphinan-17-ium Bromide
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
NT$8,778
|
8 | 5 | It can be shipped in about 2 weeks after ordering |
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* The storage conditions are subject to change without notice.
| Product Number | M3504 |
Purity / Analysis Method 
|
>95.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__2__1H__2__6BrNO__4 = 436.35 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic,Heat Sensitive |
| CAS RN | 73232-52-7 |
| Reaxys Registry Number | 8181088 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 95.0 % |
| NMR | confirm to structure |
Properties (reference)
GHS
Related Laws:
Transport Information:
| H.S.code* | 2939.19-000 |
Application
Methylnaltrexone Bromide: A Selective μ-Opioid Receptor Antagonist
Methylnaltrexone bromide is a selective antagonist of opioid binding at the μ-opioid receptor, a quaternary derivative of naltrexone [N1176]. As a quaternary amine, methylnaltrexone bromide has greater polarity and lower lipid solubility; therefore, it does not cross the blood-brain barrier.1,2) This allows methylnaltrexone bromide to act as a peripherally-acting μ-opioid receptor antagonist in tissues such as the gastrointestinal tract, thereby reducing the constipating effects of opioids without interfering with opioid-mediated analgesic effects on the central nervous system.3) (The product is for research purpose only.)
References
- 1) Receptor binding, antagonist, and withdrawal precipitating properties of opiate antagonists
- 2) Effects of opiate antagonists and their quaternary derivatives on heroin self-administration in the rat
- 3) Development of peripheral opioid antagonists: new insights into opioid effects (a review)
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