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CAS RN: 28957-04-2 | Product Number: O0387
Oridonine
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Purity: >98.0%(HPLC)
Synonyms:
- (14R)-7α,20-Epoxy-1α,6β,7,14-tetrahydroxykaur-16-en-15-one
- (1α,6β,7α,14R)-7,20-Epoxy-1,6,7,14-tetrahydroxykaur-16-en-15-one
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 50MG |
NT$6,762
|
4 | 0 | It can be shipped in about 1 week after ordering |
* The above prices include freight cost, customs, and other charges to the destination except for products that need to be shipped by sea or dry ice. For details, please contact
our distributor
in Taiwan to order our product.
* The storage conditions are subject to change without notice.
| Product Number | O0387 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__2__8O__6 = 364.44 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
50MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 28957-04-2 |
| Reaxys Registry Number | 1691227 |
| PubChem Substance ID | 468592517 |
| MDL Number | MFCD00221762 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation | -57.0 to -61.0 deg (C=0.1, ethanol) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 252 °C |
| Maximum Absorption Wavelength | 237 nm (EtOH) |
GHS
Related Laws:
| RTECS# | NZ8177000 |
Transport Information:
| H.S.code* | 2932.99-000 |
Application
Oridonin: An Active Diterpene with NLRP3 Inhibitory Activity
Oridonin (or oridonine) is an active diterpene isolated from Rabdosia rubescens used as a traditional Chinese medicine. Oridonin has been reported to possess a broad range of biological activities including anti-inflammation, anti-bacterial, anti-neoplastic and neuroprotective effects. It has recently been reported that NLR family pyrin domain-containing protein 3 (NLRP3), a pattern recognition receptor, forms a complex called NLRP3 inflammasome in response to irritating metabolites and pathogens, and induces the production of pro-inflammatory cytokines, Interleukin (IL)-1β and IL-18. Oridonin has also attracted attention as a NLRP3 inflammasome inhibitor which shows anti-inflammatory activity. (The product is for research purpose only.)
References
- Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer therapeutics (a review)
- Discovery and development of natural product oridonin-inspired anticancer agents (a review)
- Therapeutic potential of oridonin and its analogs: from anticancer and antiinflammation to neuroprotection
- Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity
- Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors (a review)
Documents
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