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CAS RN: 106516-24-9 | Product Number: S0942
Sertindole
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Purity: >95.0%(HPLC)
Synonyms:
- 1-[2-[4-[5-Chloro-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl]ethyl]-2-imidazolidinone
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
NT$4,368
|
38 | 7 | It can be shipped in about 3-4 weeks after ordering | |
| 50MG |
NT$15,540
|
24 | 1 | It can be shipped in about 3-4 weeks after ordering |
* The above prices include freight cost, customs, and other charges to the destination except for products that need to be shipped by sea or dry ice. For details, please contact
our distributor
in Taiwan to order our product.
* The storage conditions are subject to change without notice.
| Product Number | S0942 |
| Purity / Analysis Method | >95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__4H__2__6ClFN__4O = 440.95 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 10MG-Glass Bottle with Plastic Insert (View image), 50MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 106516-24-9 |
| Reaxys Registry Number | 5364890 |
| PubChem Substance ID | 253660923 |
| Merck Index (14) | 8466 |
| MDL Number | MFCD00867749 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
Properties (reference)
| Melting Point | 155 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | NJ0621100 |
Transport Information:
| H.S.code* | 2933.99-000 |
Application
Sertindole: An Antagonist at Dopamine D2, Serotonin 5-HT2A
Sertindole is an antipsychotic with high affinity for and functions as an antagonist at a number of receptor systems, including dopamine D2 receptors, serotonin 5-HT2A and 5-HT2C receptors, and α1-adrenergic receptors, and low affinity for other receptors. Sertindole undergoes extensive hepatic metabolism by the cytochrome P450 isoenzymes CYP2D6 and CYP3A4 and has an elimination half-life of approximately three days. On the other hand, sertindole can prolong the Q-T interval which is a measure of the time between the start of the Q wave and the end of the T wave in the heart's electrical cycle.
References
- Neurochemical and in vivo pharmacological profile of sertindole, a limbic-selective neuroleptic compound
- Noncataleptogenic, centrally acting dopamine D-2 and serotonin 5-HT2 antagonists within a series of 3-substituted 1-(4-fluorophenyl)-1H-indoles
- The antipsychotic agent sertindole is a high affinity antagonist of the human cardiac potassium channel HERG
- Emerging treatments in the management of schizophrenia - focus on sertindole (a review)
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