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CAS RN: 38194-50-2 | Product Number: U0099
Sulindac
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (Z)-5-Fluoro-2-methyl-1-[(p-methylsulfinyl)benzylidene]-1H-indene-3-acetic Acid
- (Z)-2-[5-Fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl]acetic Acid
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 10G |
NT$3,780
|
0 | 1 | It can be shipped in about 2 weeks after ordering | |
| 50G |
NT$14,322
|
1 | 2 | Contact Us |
* The above prices include freight cost, customs, and other charges to the destination except for products that need to be shipped by sea or dry ice. For details, please contact
our distributor
in Taiwan to order our product.
* The storage conditions are subject to change without notice.
| Product Number | U0099 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__1__7FO__3S = 356.41 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 38194-50-2 |
| PubChem Substance ID | 354334891 |
| Merck Index (14) | 8982 |
| MDL Number | MFCD00599589 |
Specifications
| Appearance | Light yellow to Brown powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 182.0 to 186.0 °C |
Properties (reference)
| Melting Point | 184 °C |
| Maximum Absorption Wavelength | 327 nm (0.05mol/L methanolic HCl) |
| Solubility in water | Insoluble |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H361 : Suspected of damaging fertility or the unborn child. H317 : May cause an allergic skin reaction. H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P272 : Contaminated work clothing should not be allowed out of the workplace. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P284 : Wear respiratory protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P304 + P340 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | NK8226000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| H.S.code* | 2930.90-900 |
Application
Sulindac: A Nonsteroidal Anti-Inflammatory Drug (NSAID) with Unique Metabolisms
Sulindac is a nonsteroidal anti-inflammatory drug that has anti-inflammatory, analgesic and antipyretic activities. The mechanism of action, like that of other NSAIDs, is not completely understood but may be related to prostaglandin synthetase inhibition. Sulindac is a unique prodrug. Slindac is reversibly metabolized to sulindac sulfide [S0906] which has anti-inflammatory and analgesic properties and is irreversibly metabolized to sulindac sulfone which has been suggested to possess antiproliferative effects against tumors. (The product is for research purpose only.)
References
- The disposition of sulindac
- Chemical and biological studies on indomethacin, sulindac and their analogs (a review)
- Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis
- Sulindac and its derivatives: a novel class of anticancer agents (a review)
- NSAID sulindac and its analog bind RXRα and inhibit RXRα-dependent AKT signaling
- Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage
- Sulindac (a review on the synthesis, physical properties, methods of detection, drug metabolism, pharmacokinetics, etc.)
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